Department of Radiation Oncology, University of Michigan Comprehensive Cancer Center, Center for RNA Biomedicine, University of Michigan, Ann Arbor, MI, United States; Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, United States.
Department of Radiation Oncology, University of Michigan Comprehensive Cancer Center, Center for RNA Biomedicine, University of Michigan, Ann Arbor, MI, United States; Department of Cell and Molecular Biology, Uppsala University, Box 256, 75105 Uppsala, Sweden.
Mutat Res Rev Mutat Res. 2019 Apr-Jun;780:48-54. doi: 10.1016/j.mrrev.2017.11.001. Epub 2017 Nov 16.
Chromatin plays a critical role in organizing and protecting DNA. However, chromatin acts as an impediment for transcription and DNA repair. Histone modifications, such as H3K79 methylation, promote transcription and genomic stability by enhancing transcription elongation and by serving as landing sites for proteins involved in the DNA damage response. This review summarizes the current understanding of the role of H3K79 methylation in transcription, how it affects genome stability and opportunities to develop impactful therapeutic interventions for cancer.
染色质在组织和保护 DNA 方面发挥着关键作用。然而，染色质阻碍转录和 DNA 修复。组蛋白修饰，如 H3K79 甲基化，通过增强转录延伸和作为参与 DNA 损伤反应的蛋白质的着陆点，促进转录和基因组稳定性。本文总结了 H3K79 甲基化在转录中的作用、它如何影响基因组稳定性以及为癌症开发有影响力的治疗干预措施的机会的现有认识。
