Forensic Medicine Division, Health Sciences Authority, 11 Outram Rd, Singapore 169078, Singapore.
Forensic Sci Int. 2019 Nov;304:109892. doi: 10.1016/j.forsciint.2019.109892. Epub 2019 Jul 26.
The use of New Psychoactive Substances (NPS) has become a serious global issue with increasing number of reports of their toxicities and fatalities. Likewise, in Singapore, the number of exhibits containing NPS detected had increased 80% from 2011 to 2014. This is a case series of the first four autopsy cases of fatalities due to or related to the use of NPS in Singapore. In one case, we present the first reported case of death due directly to ADB-FUBINACA toxicity (post-mortem blood concentration of 56ng/ml). Another case was due to 25B-NBOMe toxicity (post-mortem blood concentration of 10ng/ml) while the last two cases were deaths related to 5-Fluoro ADB, where the metabolites of the drug were detected.
新精神活性物质（NPS）的使用已成为一个严重的全球性问题，其毒性和致死报告不断增加。同样，在新加坡，2011 年至 2014 年，含有 NPS 的展品数量增加了 80%。本案例系列为新加坡首例因使用 NPS 导致或与使用 NPS 相关的 4 例尸检死亡案例。在一个案例中，我们报告了首例因 ADB-FUBINACA 毒性（死后血液浓度为 56ng/ml）直接导致的死亡案例。另一个案例是由于 25B-NBOMe 毒性（死后血液浓度为 10ng/ml）导致，而最后两例死亡与 5-Fluoro ADB 相关，在这两例死亡中检测到了药物的代谢物。
