Department of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, PR China.
Department of Epidemiology and Biostatistics, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, PR China.
Clin Nutr. 2020 Jun;39(6):1778-1784. doi: 10.1016/j.clnu.2019.07.013. Epub 2019 Jul 26.
The prevalence of childhood obesity has increased substantially. We aimed to characterize the effect of birth weight on body composition and overweight/obesity at early school age.
A total of 1669 children with available birth records from a double-blind cluster-randomized controlled trial exploring micronutrient supplementation during pregnancy were included. Data regarding school-aged body composition, social-demographic factors and health behaviours were prospectively collected.
s: The study population consisted of 1004 boys and 665 girls aged between 7 and 10 years. The prevalence of overweight/obesity (>85th age-sex-specific percentiles) was 7.4% for boys and 5.0% for girls. Generalized estimating equation models were used to account for the cluster nature of the data. A significant upward trend across quintiles of birth weight was observed for fat mass index (boys: P for trend 0.002; girls: P for trend <0.001), fat-free mass index (boys: P for trend <0.001; girls: P for trend <0.001), and percentage of body fat (boys: P for trend 0.003; girls: P for trend <0.001). A birth weight in the higher three quintiles could increase the risk ratios [RRs (95% CI) third quintile: 2.88, (1.13, 7.32); fourth quintile: 2.40, (0.87, 6.66); top quintile: 2.31, (0.92, 5.80)] of overweight/obesity at early school age compared with the RRs of the reference group (the second quintile of birth weight) among boys.
Higher birth weight could increase the risk of being overweight/obese among 7- to 10-year-old boys in rural western China. Sex differences in this association need to be considered when planning interventions.
This trial was registered at www.isrctn.com with the identifier ISRCTN08850194.
儿童肥胖症的患病率显著增加。本研究旨在描述出生体重对儿童早期体成分和超重/肥胖的影响。
本研究共纳入了 1669 名来自一项双盲、整群随机对照试验的儿童，该试验探索了孕期补充微量营养素对儿童的影响。前瞻性收集了儿童在学校阶段的体成分、社会人口统计学因素和健康行为的数据。
研究人群由 1004 名男孩和 665 名女孩组成，年龄在 7 至 10 岁之间。男孩超重/肥胖（>85 岁性别特定百分位数）的患病率为 7.4%，女孩为 5.0%。使用广义估计方程模型来解释数据的聚类性质。观察到出生体重五分位数之间存在脂肪质量指数（男孩：趋势 P 值<0.001；女孩：趋势 P 值<0.001）、无脂肪质量指数（男孩：趋势 P 值<0.001；女孩：趋势 P 值<0.001）和体脂肪百分比（男孩：趋势 P 值<0.001；女孩：趋势 P 值<0.001）的显著上升趋势。较高的出生体重可能会增加超重/肥胖的风险比（RR）[第 3 五分位数（RR，95%置信区间）：2.88（1.13，7.32）；第 4 五分位数：2.40（0.87，6.66）；第 5 五分位数：2.31（0.92，5.80）]与男孩参考组（第 2 出生体重五分位数）相比。
在中国西部农村地区，较高的出生体重可能会增加 7 至 10 岁男孩超重/肥胖的风险。在制定干预措施时，需要考虑这种关联的性别差异。
本试验在 www.isrctn.com 注册，注册号为 ISRCTN08850194。
