Department of Cognitive Science, Institute for Cognitive Science Studies, Tehran, Iran.
Department of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
J Stroke Cerebrovasc Dis. 2019 Nov;28(11):104296. doi: 10.1016/j.jstrokecerebrovasdis.2019.07.012. Epub 2019 Aug 6.
This study was designed to investigate the effect of prism adaptation (PA) combined with continuous theta-burst transcranial magnetic stimulation (cTBS) on the neglect recovery of stroke patients with unilateral neglect.
A total of 14 stroke patients with unilateral neglect were randomly assigned to 2 groups including an intervention group undergone PA combined with cTBS over the left intact parietal cortex and a control group. PA combined with sham cTBS was perfomed for 2 weeks in 10 daily sessions. Before and after the intervention, patients were evaluated for visuospatial neglect measured using the Star Cancellation Test (SCT), Line Bisection Task (LBT), Figure Copying Test, and Clock Drawing Task. Neurological function was evaluated using the Modified Rankin Scale (MRS).
Both groups (PA alone and PA+ cTBS) showed improvement in their neglected symptoms (measured by SCT, LBT, Figure Copying Test, and Clock Drawing Task), and in their disability in the neurological function (measured by MRS) (P< .05).
The results of the present study showed that, transcranial magnetic stimulation did not increase the effect of PA on neglect symptoms in stroke patients.
本研究旨在探讨棱镜适应（PA）联合连续 theta 爆发经颅磁刺激（cTBS）对单侧忽略脑卒中患者恢复的影响。
将 14 例单侧忽略脑卒中患者随机分为 2 组，干预组接受左完整顶叶皮质区 PA 联合 cTBS，对照组接受 PA 联合假 cTBS。2 组均接受 10 次/日、共 2 周的治疗。干预前后分别采用星号删除测验（SCT）、线二分测验（LBT）、图形复制测验和画钟测验评估视空间忽略，采用改良 Rankin 量表（MRS）评估神经功能缺损。
PA 联合 cTBS 组和 PA 组的忽略症状（SCT、LBT、图形复制测验和画钟测验）和神经功能缺损（MRS）均有所改善（P<0.05）。
本研究结果表明，经颅磁刺激并未增加 PA 对脑卒中患者忽略症状的治疗效果。
