采用重 T2 加权液体衰减反转恢复成像技术对脑脊液中细微钆渗漏的最佳检测。
Optimal Detection of Subtle Gadolinium Leakage in CSF with Heavily T2-Weighted Fluid-Attenuated Inversion Recovery Imaging.
机构信息
From the Department of Psychiatry and Neuropsychology (W.M.F., R.W.v.H., H.I.L.J., F.R.V.), Maastricht University, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht, the Netherlands.
Department of Radiology and Nuclear Medicine (W.M.F., W.M.P., J.F.A,J., W.H.B.), Maastricht University Medical Center, School for Mental Health and Neuroscience, Maastricht, the Netherlands.
出版信息
AJNR Am J Neuroradiol. 2019 Sep;40(9):1481-1483. doi: 10.3174/ajnr.A6145. Epub 2019 Aug 8.
Abstract
Pericortical enhancement on postcontrast FLAIR images is a marker for subtle leptomeningeal blood-brain barrier leakage. We explored the optimal FLAIR sequence parameters for the detection of low gadolinium concentrations within the CSF. On the basis of phantom experiments and human in vivo data, we showed that detection of subtle pericortical enhancement can be facilitated by using a relatively long TE. Future studies should choose their FLAIR sequence parameters carefully when assessing pericortical enhancement due to subtle blood-brain barrier leakage.
摘要
皮质周围增强在对比后 FLAIR 图像上是细微脑膜血脑屏障渗漏的标志物。我们探索了最佳的 FLAIR 序列参数，以检测 CSF 中的低钆浓度。基于体模实验和人体体内数据，我们表明使用相对较长的 TE 可以促进细微皮质周围增强的检测。未来的研究在评估由于细微血脑屏障渗漏导致的皮质周围增强时，应该仔细选择 FLAIR 序列参数。
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