FLAIR 磁共振成像上的急性再灌注高亮信号标记物是由脑脊液中的钆导致的。
The hyperintense acute reperfusion marker on fluid-attenuated inversion recovery magnetic resonance imaging is caused by gadolinium in the cerebrospinal fluid.
机构信息
Department of Neurology, University Hospital of Erlangen, Erlangen, Germany.
出版信息
Stroke. 2012 Jan;43(1):259-61. doi: 10.1161/STROKEAHA.111.632356. Epub 2011 Oct 6.
BACKGROUND AND PURPOSE
The hyperintense acute reperfusion marker (HARM) on fluid-attenuated inversion recovery MRI is believed to be caused by gadolinium-based contrast agents crossing a disrupted blood-brain barrier. However, this hypothesis has never been directly verified in humans.
METHODS
In this study, we analyzed cerebrospinal fluid samples of patients with HARM on imaging regarding the presence and concentration of gadolinium-based contrast agents.
RESULTS
Gadobutrol was found in concentrations of approximately 50 μmol/L. Using phantom MRI experiments, we demonstrate that the detected concentrations are consistent with the observed HARM imaging pattern.
CONCLUSIONS
Our study yields first direct evidence in humans that the imaging phenomenon HARM is indeed caused by leakage of gadolinium-based contrast agents into the cerebrospinal fluid.
背景与目的
磁共振成像液体衰减反转恢复序列（FLAIR）上的高信号急性再灌注标记物（HARM）被认为是由钆基造影剂穿过破坏的血脑屏障引起的。然而，这一假说从未在人类中得到直接验证。
方法
本研究分析了影像学上有 HARM 的患者的脑脊液样本，以检测其中是否存在和浓度是否存在钆基造影剂。
结果
检测到浓度约为 50 μmol/L 的gadobutrol。通过磁共振成像（MRI）实验，我们证明检测到的浓度与观察到的 HARM 成像模式一致。
结论
本研究首次在人体中直接证实，HARM 这种影像学现象确实是由钆基造影剂漏入脑脊液引起的。
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