Department of Mechanical Engineering, Imperial College London, London, SW7 2AZ, UK.
Mars Petcare, Oakwell Way, Birstall, Batley, WF17 9LU, UK.
Nat Commun. 2019 Aug 8;10(1):3571. doi: 10.1038/s41467-019-11288-5.
Oral biofilm accumulation in pets is a growing concern. It is desirable to address this problem via non-invasive teeth cleaning techniques, such as through friction between teeth and food during chewing. Therefore, pet food design tools are needed towards optimising cleaning efficacy. Developing such tools is challenging, as several parameters affecting teeth cleaning should be considered: the food's complex mechanical response, the contacting surfaces topology as well as the wide range of masticatory and anatomical characteristics amongst breeds. We show that Finite Element (FE) models can efficiently account for all these parameters, through the simulation of food deformation and fracture during the first bite. This reduces the need for time consuming and costly in-vivo or in-vitro trials. Our in-silico model is validated through in-vitro tests, demonstrating that the initial oral processing stage can be engineered through computers with high fidelity.
宠物口腔内生物膜的积累是一个日益严重的问题。通过非侵入性的牙齿清洁技术来解决这个问题是很有必要的,例如通过咀嚼时牙齿和食物之间的摩擦。因此,需要宠物食品设计工具来优化清洁效果。开发这样的工具是具有挑战性的,因为有几个影响牙齿清洁的参数需要考虑:食物的复杂力学响应、接触表面的拓扑结构以及品种间广泛的咀嚼和解剖特征。我们通过模拟第一次咬合过程中食物的变形和断裂,表明有限元(FE)模型可以有效地考虑所有这些参数。这减少了对耗时且昂贵的体内或体外试验的需求。我们的计算机模拟模型通过体外试验进行了验证,证明了初始口腔处理阶段可以通过计算机以高精度进行设计。