一种在诱导抗肿瘤免疫方面有效的合成佐剂。
A synthetic adjuvant effective in inducing antitumor immunity.
作者信息
Kataoka T, Tokunaga T
机构信息
Department of Cellular Immunology, National Institute of Health, Tokyo.
出版信息
Jpn J Cancer Res. 1988 Jul;79(7):817-20. doi: 10.1111/j.1349-7006.1988.tb00042.x.
Abstract
Guinea pigs which were injected repeatedly with a mixture of a 3M KCl extract of line 10 tumor and 6-O-(2-tetradecyl-hexadecanoyl)-muramyl-dipeptide (B30-MDP) rejected a tumor graft of line 10. Such an adjuvant effect of B30-MDP was also demonstrated when X-ray-treated line 10 cells were mixed with B30-MDP dissolved in phosphate-buffered saline and inoculated into the animals.
摘要
将10号线肿瘤的3M KCl提取物与6-O-(2-十四烷基-十六烷酰基)-胞壁酰二肽（B30-MDP）的混合物反复注射的豚鼠排斥了10号线的肿瘤移植。当用X射线处理过的10号线细胞与溶解在磷酸盐缓冲盐水中的B30-MDP混合并接种到动物体内时，也证明了B30-MDP的这种佐剂作用。
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