在可代谢油中与抗原一起给予胞壁酰二肽衍生物后，细胞介导的和抗体免疫反应持续增强。
Persistent enhancement of cell-mediated and antibody immune responses after administration of muramyl dipeptide derivatives with antigen in metabolizable oil.
作者信息
Carelli C, Audibert F, Chedid L
出版信息
Infect Immun. 1981 Jul;33(1):312-4. doi: 10.1128/iai.33.1.312-314.1981.
Abstract
Circulating antibody titers can be increased when the antigen is administered in an aqueous medium with N-acetylmuramyl-L-alanyl-D-isoglutamine (muramyl dipeptide). Results reported here show that cell-mediated immunity can be demonstrated when this synthetic adjuvant or an active analog is injected with an antigen (ovalbumin) in metabolizable squalane emulsion. Under these conditions a lipophilic derivative of muramyl dipeptide was shown to be even more active and to enhance long-lasting immune responses.
摘要
当抗原与N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺（胞壁酰二肽）在水性介质中给药时，循环抗体滴度会升高。此处报道的结果表明，当这种合成佐剂或活性类似物与抗原（卵清蛋白）一起注射到可代谢的角鲨烷乳剂中时，可以证明细胞介导的免疫反应。在这些条件下，胞壁酰二肽的亲脂性衍生物显示出更强的活性，并能增强持久的免疫反应。
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