Knapp M R, Jones P P, Black S J, Vitetta E S, Slavin S, Strober S
J Immunol. 1979 Sep;123(3):992-9.
The surface marker expression of a spontaneous B lymphocyte leukemia discovered in a BALB/c mouse (BCL1) was examined and found to include a subset of markers known to occur on normal B lymphocytes. The tumor cells bore surface Ig that included both mu- and delta-chains associated with the lambda light chain. Alloantigens coded for within the murine MHC, including H-2D, H-2K, and I-region products, were identified on the tumor cells. Although normal B lymphocytes are thought to express products coded for within both the I-A and I-E subregions, the BCL1 expressed only normal amounts of I-E subregion products. In addition, the H-2 and Ia antigens revealed by 2-dimensional gel electrophoresis exhibited an abnormal pattern of post-translational modifications. The Fc, but not the complement-receptor, was present on the surface of tumor cells. The presence of IgD, Ia antigens, and the responsiveness to lipopolysaccharide (see subsequent paper) have led us to postulate that the BCL1 tumor represents a later differentiative stage than murine B lymphocyte tumors previously described.
对在一只BALB/c小鼠（BCL1）中发现的自发性B淋巴细胞白血病的表面标志物表达进行了检测，发现其包括已知在正常B淋巴细胞上出现的一部分标志物。肿瘤细胞带有表面免疫球蛋白，其中包括与λ轻链相关的μ链和δ链。在肿瘤细胞上鉴定出了鼠类主要组织相容性复合体（MHC）编码的同种异体抗原，包括H-2D、H-2K和I区产物。虽然正常B淋巴细胞被认为表达I-A和I-E两个亚区编码的产物，但BCL1仅表达正常量的I-E亚区产物。此外，二维凝胶电泳显示的H-2和Ia抗原呈现出异常的翻译后修饰模式。肿瘤细胞表面存在Fc，但不存在补体受体。IgD、Ia抗原的存在以及对脂多糖的反应性（见后续论文）使我们推测，BCL1肿瘤代表了一个比先前描述的鼠类B淋巴细胞肿瘤更晚期的分化阶段。
