Muirhead M J, Isakson P C, Krolick K A, Uhr J W, Vitetta E S
Am J Pathol. 1981 Dec;105(3):295-305.
BCL1 is a transplantable murine B-cell leukemia that closely resembles human prolymphocytic leukemia (PLL). Syngeneic mice injected with BCL1 cells develop massively enlarged spleens followed by leukemia. Splenectomy performed either prior to BCL1 transplantation or prior to the leukemic phase of transplanted BCL1 results in a markedly altered clinical syndrome: the onset of leukemia is delayed by about 2 months; the leukemia is low-grade; and the lymph nodes, which are not prominently involved in leukemic animals with intact spleens, are massively infiltrated in the splenectomized transplant recipient. The immunologic phenotype of the BCL1 cell is not altered by splenectomy and thus does not appear to account for the altered tissue distribution of BCL1 in the splenectomized host. However, the results indicate a striking dependence of BCL1 on microenvironmental influences of the host lymphoid tissues.
BCL1是一种可移植的小鼠B细胞白血病，与人类幼淋巴细胞白血病（PLL）极为相似。注射BCL1细胞的同基因小鼠会出现脾脏大量肿大，随后发展为白血病。在BCL1移植前或移植的BCL1进入白血病阶段前进行脾切除术，会导致临床综合征明显改变：白血病的发病延迟约2个月；白血病为低级别；在脾脏完整的白血病动物中未显著受累的淋巴结，在脾切除的移植受体中会大量浸润。脾切除术不会改变BCL1细胞的免疫表型，因此似乎不能解释BCL1在脾切除宿主中组织分布的改变。然而，结果表明BCL1对宿主淋巴组织的微环境影响有显著依赖性。
