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Acquisition of cell surface IgD after in vitro culture of neoplastic B cells from the murine tumor BCL1.对来自小鼠肿瘤BCL1的肿瘤性B细胞进行体外培养后获得细胞表面IgD。
J Exp Med. 1980 Mar 1;151(3):749-54. doi: 10.1084/jem.151.3.749.
2
Cell surface immunoglobulin. XIX. Susceptibility of IgD and IgM on murine splenocytes to cleavage by papain.细胞表面免疫球蛋白。十九。小鼠脾细胞上IgD和IgM对木瓜蛋白酶裂解的敏感性。
J Immunol. 1976 Nov;117(5 Pt 1):1579-83.
3
Differential endocytosis of IgM and IgD in murine B cell lines.小鼠B细胞系中IgM和IgD的差异性内吞作用。
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Expression of IgD by murine lymphocytes. Loss of surface IgD indicates maturation of memory B cells.小鼠淋巴细胞IgD的表达。表面IgD的缺失表明记忆B细胞的成熟。
J Exp Med. 1978 Apr 1;147(4):984-96. doi: 10.1084/jem.147.4.984.
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Cold Spring Harb Symp Quant Biol. 1977;41 Pt 1:185-91. doi: 10.1101/sqb.1977.041.01.024.
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Continuous culturing of murine splenic B-lumphocytes: synthesis and surface deposition of IgM and putative IgD molecules.小鼠脾脏B淋巴细胞的连续培养：IgM和假定IgD分子的合成与表面沉积
Cell. 1976 Jul;8(3):397-403. doi: 10.1016/0092-8674(76)90152-5.

引用本文的文献

1
BCL1, a murine model of prolymphocytic leukemia. I. Effect of splenectomy on growth kinetics and organ distribution.BCL1，一种幼淋巴细胞白血病的小鼠模型。I. 脾切除对生长动力学和器官分布的影响。
Am J Pathol. 1981 Dec;105(3):295-305.
2
Hydroxyurea increases in vitro, antigen-independent B cell development in bone marrow.羟基脲可增加体外骨髓中不依赖抗原的B细胞发育。
Clin Exp Immunol. 1982 Sep;49(3):695-700.
3
BCL1, a murine model of prolymphocytic leukemia. II. Morphology and ultrastructure.BCL1，一种幼淋巴细胞白血病的小鼠模型。II. 形态学与超微结构
Am J Pathol. 1981 Dec;105(3):306-15.
4
Induction of proliferation and differentiation of neoplastic B cells by anti-immunoglobulin and T-cell factors.抗免疫球蛋白和T细胞因子诱导肿瘤性B细胞的增殖与分化
Proc Natl Acad Sci U S A. 1981 Apr;78(4):2507-11. doi: 10.1073/pnas.78.4.2507.
5
Treatment of lymphoid tumors with anti-idiotype antibodies.用抗独特型抗体治疗淋巴瘤。
Springer Semin Immunopathol. 1983;6(1):99-115. doi: 10.1007/BF01857369.
6
Secretion of idiotypic IgM by the mouse B-cell leukaemia (BCL1) occurs spontaneously in vitro and in vivo.小鼠B细胞白血病（BCL1）产生的独特型IgM在体内外均可自发分泌。
Immunology. 1985 May;55(1):59-63.
7
Double isotype production by a neoplastic B cell line. II. Allelically excluded production of mu and gamma 1 heavy chains without CH gene rearrangement.肿瘤性B细胞系的双同种型产生。II. 无CH基因重排的μ链和γ1重链的等位基因排斥产生
J Exp Med. 1986 Aug 1;164(2):562-79. doi: 10.1084/jem.164.2.562.

本文引用的文献

1
Murine B cell leukemia (BCL1): organ distribution and kinetics of growth as determined by fluorescence analysis with an anti-idiotypic antibody.小鼠B细胞白血病（BCL1）：通过抗独特型抗体荧光分析确定的器官分布及生长动力学
J Immunol. 1979 Nov;123(5):1928-35.
2
Characterization of a spontaneous murine B cell leukemia (BCL1). II. Tumor cell proliferation and IgM secretion after stimulation by LPS.自发性小鼠B细胞白血病（BCL1）的特征。II. 脂多糖刺激后肿瘤细胞的增殖和IgM分泌
J Immunol. 1979 Sep;123(3):1000-6.
3
Characterization of a spontaneous murine B cell leukemia (BCL1). I. Cell surface expression of IgM, IgD, Ia, and FcR.自发性小鼠B细胞白血病（BCL1）的特征。I. IgM、IgD、Ia和FcR的细胞表面表达
J Immunol. 1979 Sep;123(3):992-9.
4
Induction of in vitro differentiation and immunoglobulin synthesis of human leukemic B lymphocytes.人白血病B淋巴细胞体外分化及免疫球蛋白合成的诱导
J Exp Med. 1978 Dec 1;148(6):1570-8. doi: 10.1084/jem.148.6.1570.
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Spontaneous murine B-cell leukaemia.自发性小鼠B细胞白血病
Nature. 1978 Apr 13;272(5654):624-6. doi: 10.1038/272624a0.
6
Surface immunoglobulins of lipopolysaccharide-stimulated spleen cells. The behavior of IgM, IgD and IgG.脂多糖刺激的脾细胞的表面免疫球蛋白。IgM、IgD和IgG的行为
Eur J Immunol. 1977 Mar;7(3):151-3. doi: 10.1002/eji.1830070307.
7
Characterization of the spontaneous murine B cell leukemia (BCL1). III. Evidence for monoclonality by using an anti-idiotype antibody.自发性小鼠B细胞白血病（BCL1）的特征。III. 使用抗独特型抗体证明单克隆性。
J Immunol. 1979 May;122(5):1649-54.
8
Rescue of immunoglobulin secretion from human neoplastic lymphoid cells by somatic cell hybridization.通过体细胞杂交拯救人肿瘤性淋巴细胞的免疫球蛋白分泌
Proc Natl Acad Sci U S A. 1978 May;75(5):2411-5. doi: 10.1073/pnas.75.5.2411.
9
BCL1, a murine model for chronic lymphocytic leukemia: use of the surface immunoglobulin idiotype for the detection and treatment of tumor.BCL1，一种慢性淋巴细胞白血病的小鼠模型：利用表面免疫球蛋白独特型检测和治疗肿瘤。
Immunol Rev. 1979;48:81-106. doi: 10.1111/j.1600-065x.1979.tb00299.x.
10
IgD and B cell differentiation.免疫球蛋白D与B细胞分化
Immunol Rev. 1977;37:50-88. doi: 10.1111/j.1600-065x.1977.tb00245.x.

对来自小鼠肿瘤BCL1的肿瘤性B细胞进行体外培养后获得细胞表面IgD。

Acquisition of cell surface IgD after in vitro culture of neoplastic B cells from the murine tumor BCL1.

作者信息

Isakson P C, Uhr J W, Krolick K A, Finkelman F, Vitetta E S

出版信息

J Exp Med. 1980 Mar 1;151(3):749-54. doi: 10.1084/jem.151.3.749.

DOI:10.1084/jem.151.3.749
PMID:6987329
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2185800/
Abstract

Murine BCL1 tumor cells bear large amounts of surface IgM and trace amounts of surface IgD. In the present studies we have shown that cultivation of these cells, in the absence of lipopolysaccharide, results in the acquisition of IgD by virtually all the cells. These results suggest that BCL1 cells can differentiate in vitro into more mature B cells and offer an attractive model for analyzing the factors controlling appearance of IgD on a monoclonal cell line.

摘要

小鼠BCL1肿瘤细胞带有大量表面免疫球蛋白M（IgM）和微量表面免疫球蛋白D（IgD）。在本研究中，我们已表明，在无脂多糖的情况下培养这些细胞，几乎所有细胞都会获得IgD。这些结果表明，BCL1细胞可在体外分化为更成熟的B细胞，并为分析控制单克隆细胞系上IgD出现的因素提供了一个有吸引力的模型。