对来自小鼠肿瘤BCL1的肿瘤性B细胞进行体外培养后获得细胞表面IgD。
Acquisition of cell surface IgD after in vitro culture of neoplastic B cells from the murine tumor BCL1.
作者信息
Isakson P C, Uhr J W, Krolick K A, Finkelman F, Vitetta E S
出版信息
J Exp Med. 1980 Mar 1;151(3):749-54. doi: 10.1084/jem.151.3.749.
Abstract
Murine BCL1 tumor cells bear large amounts of surface IgM and trace amounts of surface IgD. In the present studies we have shown that cultivation of these cells, in the absence of lipopolysaccharide, results in the acquisition of IgD by virtually all the cells. These results suggest that BCL1 cells can differentiate in vitro into more mature B cells and offer an attractive model for analyzing the factors controlling appearance of IgD on a monoclonal cell line.
摘要
小鼠BCL1肿瘤细胞带有大量表面免疫球蛋白M（IgM）和微量表面免疫球蛋白D（IgD）。在本研究中，我们已表明，在无脂多糖的情况下培养这些细胞，几乎所有细胞都会获得IgD。这些结果表明，BCL1细胞可在体外分化为更成熟的B细胞，并为分析控制单克隆细胞系上IgD出现的因素提供了一个有吸引力的模型。
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