Department of General, Vascular Surgery, Angiology and Phlebology Faculty of Katowice Medical University of Silesia, Faculty of Medicine in Katowice, Medical University of Silesia, Poniatowskiego Str 15, 40-055 Katowice, Poland.
Department of Anaesthesiology and Intensive Care, Upper-Silesian Medical Centre of the Silesian Medical University, Ziołowa 45, 40-635 Katowice, Poland.
Mediators Inflamm. 2019 Jul 17;2019:3767128. doi: 10.1155/2019/3767128. eCollection 2019.
Knowledge about the influence of inflammation on platelet function and relocation of hemostatic balance to hypercoagulable state is still unclear. We compared two groups of patients who suffer from acute vs. chronic inflammatory process and additionally present high on-treatment platelet reactivity-dual platelet resistance. We did not found any differences in platelet aggregation between both investigated groups, but patients who suffer from chronic inflammation presented stronger relocation of the hemostatic balance to the hypercoagulability. A high concentration of prothrombin fragment F1+2 together with higher activity of von Willebrand factor in critical limb ischemia shows more exaggerated fibrinogen turnover although the blood concentration of this factor was in normal range. We concluded that high on-treatment platelet reactivity-dual platelet resistance and intensified inflammation are linked with elevated platelet and fibrinogen turnover to counteract proper hemostatic balance in favor of a prothrombotic state.
关于炎症对血小板功能和止血平衡向高凝状态转移的影响的知识仍不清楚。我们比较了两组患有急性和慢性炎症过程且同时存在高治疗后血小板反应性-双血小板抵抗的患者。我们没有发现两个研究组之间的血小板聚集有任何差异，但患有慢性炎症的患者止血平衡向高凝状态的转移更强烈。在严重肢体缺血中，凝血酶原片段 F1+2 浓度升高以及血管性血友病因子活性升高表明纤维蛋白原周转率更高，尽管该因子的血液浓度处于正常范围。我们得出结论，高治疗后血小板反应性-双血小板抵抗和炎症加剧与血小板和纤维蛋白原周转率升高有关，以对抗适当的止血平衡，有利于血栓形成状态。
