Costa Paulo Zoé, Chorão Pedro, Póvoa Andreia, Vieira Pedro, Cabrera Heidy, Mendes Orlando, Evangelista Céu
Department of Internal Medicine, Unidade Local de Saúde da Guarda E.P.E., Guarda 6301-857, Portugal.
Department of Clinical Hematology, Centro Hospitalar São João E.P.E., Porto 4200-319, Portugal.
Case Rep Med. 2019 Jul 14;2019:9581605. doi: 10.1155/2019/9581605. eCollection 2019.
Waldenström macroglobulinemia (WM) is a type of non-Hodgkin lymphoma in which cancer cells produce large amounts of an abnormal protein that can cause hyperviscosity syndrome (HVS). A 43-year-old woman with WM, who developed seizures, had a head computed tomography scan that showed signs of cerebral venous thrombosis (CVT). Nevertheless, the value of immunoglobulin M was lower than 50 g/L, and evaluation of serum viscosity was not performed. Moreover, there was no history of bleeding, and the eye funduscopy was normal. These findings lead to think of causes of CVT other than HVS in a patient with WM.
华氏巨球蛋白血症（WM）是一种非霍奇金淋巴瘤，其中癌细胞会产生大量可导致高黏滞综合征（HVS）的异常蛋白质。一名患有WM的43岁女性出现癫痫发作，头部计算机断层扫描显示有脑静脉血栓形成（CVT）的迹象。然而，免疫球蛋白M的值低于50g/L，且未进行血清黏度评估。此外，没有出血史，眼底检查正常。这些发现使人想到该WM患者CVT的病因是HVS以外的其他因素。
