Mu Yan-Yun, Hua Qi-Xin, Yao Bing, Feng Yu-Ming, Xie Zheng-Yun, Gao Zhao, Zhang Wen-Jing, Xia You-Bing
Second Clinical Medical College, Nanjing University of CM, Nanjing 210023, Jiangsu Province, China.
Department of Acupuncture and Moxibustion, Nanjing Hospital of TCM.
Zhongguo Zhen Jiu. 2019 Aug 12;39(8):843-8. doi: 10.13703/j.0255-2930.2019.08.012.
To observe the clinical effect of grain-moxibustion combined with medicine therapy for asthenospermia and oligospermia.
A tatal of 60 patients were randomized into an observation group (30 cases) and a control group (30 cases) according to 1︰1 ratio. In the control group, vitamin E capsules were taken orally one capsule each time, twice a day, and pills 6 g each time, three times a day for a total of 3 months. In the observation group, grain-moxibustion was applied at Guanyuan (CV 4)，Shenshu (BL 23) and Zusanli (ST 36) based on the control group, once a week for 3 months, with a total of 12 times. The sperm concentration and sperm progressive motility were measured by automatic sperm quality analysis system in the two groups, and the clinical effects were compared. Sperm DNA fragmentation index (DFI) in the observation group was measured by sperm nucleus chromosome structure assay (SCSA).
①The sperm concentrations and sperm progressive motilities after 1-month, 2-month and 3-month of treatment were increased compared with those before treatment in the two groups (<0.01), and they were increased with time. In the two groups, 2-month and 1-month of treatment, 3-month and 2-month of treatment were compared, the sperm concentrations and sperm progressive motilities were significantly increased (<0.01). The sperm concentrations after 1-month, 2-month and 3-month of treatment in the observation group were higher than those in the control group (<0.01), the sperm progressive motility after 3-month of treatment in the observation group was higher than that in the control group (<0.05). ②After 3-month of treatment，the DFI in the observation group was significantly reduced compared with that before treatment (<0.01). ③The total effective rate in the observation group after 3-month of treatment was 86.7% (26/30), which was superior to 63.3% (19/30) in the control group (<0.05).
Grain-moxibustion combined with medicine therapy can improve sperm concentration and sperm progressive motility, enhance the integrity of sperm DNA.
观察麦粒灸结合药物治疗弱精子症和少精子症的临床疗效。
将60例患者按1∶1比例随机分为观察组（30例）和对照组（30例）。对照组口服维生素E胶囊，每次1粒，每日2次， 每次6 g，每日3次，共治疗3个月。观察组在对照组治疗基础上，加用麦粒灸关元（CV 4）、肾俞（BL 23）、足三里（ST 36），每周1次，共治疗3个月，共12次。两组均采用自动精子质量分析系统检测精子浓度和精子前向运动率，并比较临床疗效。观察组采用精子核染色体结构分析（SCSA）检测精子DNA碎片指数（DFI）。
①两组治疗1个月、2个月、3个月后的精子浓度和精子前向运动率均较治疗前升高（<0.01），且随时间延长而升高。两组治疗2个月与1个月、3个月与2个月比较，精子浓度和精子前向运动率均显著升高（<0.01）。观察组治疗1个月、2个月、3个月后的精子浓度均高于对照组（<0.01），观察组治疗3个月后的精子前向运动率高于对照组（<0.05）。②治疗3个月后，观察组DFI较治疗前显著降低（<0.01）。③观察组治疗3个月后的总有效率为86.7%（26/30），优于对照组的63.3%（19/30）（<0.05）。
麦粒灸结合药物治疗可提高精子浓度和精子前向运动率，增强精子DNA的完整性。
