过氧化物酶敏感可扩增探针用于肺部炎症的分子磁共振成像。
Peroxidase Sensitive Amplifiable Probe for Molecular Magnetic Resonance Imaging of Pulmonary Inflammation.
机构信息
The Institute for Innovation in Imaging , A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School , Charlestown , Massachusetts 02129 , United States.
Division of Pulmonary and Critical Care Medicine and the Center for Immunology and Inflammatory Diseases , Massachusetts General Hospital , Boston , Massachusetts 02114 , United States.
出版信息
ACS Sens. 2019 Sep 27;4(9):2412-2419. doi: 10.1021/acssensors.9b01010. Epub 2019 Aug 22.
Abstract
An amplifiable magnetic resonance imaging (MRI) probe that combines the stability of the macrocyclic Gd-DOTAGA core with a peroxidase-reactive 5-hydroxytryptamide (5-HT) moiety is reported. The incubation of the complex under enzymatic oxidative conditions led to a 1.7-fold increase in at 1.4 T that was attributed to an oligomerization of the probe upon oxidation. This probe, Gd-5-HT-DOTAGA, provided specific detection of lung inflammation by MRI in bleomycin-injured mice.
摘要
一种可扩增的磁共振成像（MRI）探针，它结合了大环 Gd-DOTAGA 核的稳定性和具有过氧化物酶反应性的 5-羟色胺（5-HT）部分。该复合物在酶促氧化条件下孵育导致在 1.4 T 下的增加了 1.7 倍，这归因于探针在氧化时的寡聚化。该探针 Gd-5-HT-DOTAGA 通过 MRI 特异性检测博来霉素损伤小鼠的肺部炎症。
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