Baarsma E A, Rijntjes E
J Laryngol Otol. 1979 Jul;93(7):725-7. doi: 10.1017/s0022215100087600.
The case histories are described of two patients with normal renal function who developed permanent complete bilateral loss of peripheral vestibular function during tobramycin therapy. Despite the low incidence of the cochleotoxic and and vestibulotoxic side-effects of tobramycin, it seems advisable to monitor patients on tobramycin therapy for signs of vestibular dysfunction and hearing loss.
描述了两名肾功能正常的患者的病例史，他们在妥布霉素治疗期间出现了永久性双侧外周前庭功能完全丧失。尽管妥布霉素的耳蜗毒性和前庭毒性副作用发生率较低，但对接受妥布霉素治疗的患者监测前庭功能障碍和听力损失的迹象似乎是明智的。
