Fernandez-Noval A, Leroy F
J Endocrinol. 1979 Jun;81(3):351-4. doi: 10.1677/joe.0.0810351.
Pregnant mice were ovariectomized 3 days after mating and pregnancy was maintained by progesterone treatment. Different regimens of intraperitoneal injections of 3'-deoxyadenosine were applied 3 days after ovariectomy. Repetition of the injections at 3 h intervals induced a significant rate of implantation by delayed blastocysts. Other types of treatment with 3-deoxyadenosine as well as adenosine injections were found to be ineffective. Paradoxically, 3'-deoxyadenosine treatment had an adverse effect on the overall pregnancy rate found at autopsy.
怀孕小鼠在交配后3天进行卵巢切除术，并通过孕酮治疗维持妊娠。卵巢切除术后3天采用不同的腹腔注射3'-脱氧腺苷方案。每隔3小时重复注射可诱导延迟胚泡的着床率显著提高。发现3'-脱氧腺苷的其他治疗类型以及腺苷注射均无效。矛盾的是，3'-脱氧腺苷治疗对尸检时发现的总体妊娠率有不利影响。
