Webb F T
J Reprod Fertil. 1975 Mar;42(3):511-7. doi: 10.1530/jrf.0.0420511.
Experiments are described that demonstrate that uterine intraluminal injection of a 1-25 mM-solution of dibutyryl cyclic AMP (dcAMP) in phosphate buffered saline (PBS) induced implantation in ovariectomized pregnant mice. Pretreatment with progesterone was essential for this effect. When PBS was injected alone, it did not induce implantation in mice treated with progesterone. Bilateral adrenalectomy had no effect on the ability of dcAMP to substitute for oestradiol, showing that the effect was not due to dcAMP-induced oestrogen synthesis in the adrenal cortex. It is suggested that the dcAMP may act at the level of the uterus, the embryo, or both.
所描述的实验表明，在磷酸盐缓冲盐水（PBS）中向子宫腔内注射1 - 25 mM的二丁酰环磷腺苷（dcAMP）溶液可诱导去卵巢怀孕小鼠着床。孕酮预处理对这种效应至关重要。单独注射PBS时，在用孕酮处理的小鼠中不会诱导着床。双侧肾上腺切除术对dcAMP替代雌二醇的能力没有影响，表明该效应不是由于dcAMP诱导肾上腺皮质合成雌激素所致。有人提出，dcAMP可能在子宫或胚胎水平或两者都起作用。
