Department of Dermatology, Hospital Universitario de Fuenlabrada, Madrid, Spain; Universidad Rey Juan Carlos, Madrid, Spain.
School of Agricultural, Food and Biosystems Engineering, Universidad Politécnica de Madrid, Madrid, Spain.
Photodiagnosis Photodyn Ther. 2019 Dec;28:192-194. doi: 10.1016/j.pdpdt.2019.08.011. Epub 2019 Aug 6.
An observational study was carried out in the photodynamic therapy (PDT) section of Fuenlabrada's hospital (Madrid, Spain). Our goal was to investigate the efficacy and safety of PDT in Bowen's disease (BD). Between June 2011-June 2017 171 patients (191 lesions) with diagnosis of BD were enrolled in the study (95 women and 76 men; average age of 74.31 years). Lesions were treated with one 5-aminolaevulinic acid (BF-200 ALA)-PDT or methyl-5-aminolaevulinate (MAL)-PDT cycle of two sessions in one week. A second treatment cycle was performed in cases of clinical persistence at 12 weeks. Our results showed that 47/55 lesions were resolved (84.75%) after one or two ALA-PDT cycle and 75/136 lesions (55.15%) after one or two MAL-PDT cycles, in the 12-month follow-up. In conclusion PDT is a safe and non-invasive treatment option in BD. In addition, our results suggest a better response with ALA-PDT over MAL-PDT. Limits: observational study with a limited number of patients.
本研究在西班牙马德里富恩拉夫拉达（Fuenlabrada）医院的光动力疗法（PDT）科进行。我们的目标是研究 PDT 在鲍文病（BD）中的疗效和安全性。2011 年 6 月至 2017 年 6 月期间，共有 171 例（191 处病变）BD 患者（95 名女性和 76 名男性；平均年龄 74.31 岁）入组该研究。病变采用单剂 5-氨基酮戊酸（BF-200 ALA）-PDT 或二甲基-5-氨基酮戊酸（MAL）-PDT 治疗，每周一次，共两个疗程。在 12 周时若临床仍有残留，进行第二次治疗周期。我们的结果显示，在 12 个月的随访中，55 处病变中有 47 处（84.75%）经一个或两个 ALA-PDT 周期治疗后消退，136 处病变中有 75 处（55.15%）经一个或两个 MAL-PDT 周期治疗后消退。结论：PDT 是 BD 的一种安全、非侵入性的治疗选择。此外，我们的结果表明，ALA-PDT 的疗效优于 MAL-PDT。局限性：本研究为观察性研究，患者数量有限。
