Musil V, Homola L, Vrba M, Braunová A, Kravalová T, Malá M, Krbková L
Epidemiol Mikrobiol Imunol. 2019 Spring;68(2):59-64.
Despite an increasing trend in Clostridium difficile infections (CDI) and high C. difficile colonization rate especially among younger children, infants remain quite resistant to the disease. The goals of this study were to distinguish whether there exists a difference in CDI between children with or without diarrhoea, ascertain the prevalence of CDI, and assess CDI severity in children under 3 years with diarrhoea in our institution.
A prospective study was conducted from May 2015 to June 2016. Children 3 years of age or younger were enrolled and into two groups. Every faecal sample was tested using a diagnostic two-step screening algorithm including an immunochromatographic test and polymerase chain reaction.
The study enrolled 147 children with diarrhoea and 75 control patients. The prevalence of CDI in children with diarrhoea was 2% (3/147), the prevalence of toxigenic C. difficile in the diarrhoeal group compared to the control group was 11.6 % (17/147) vs. 10.6% (8/75) (p.
尽管艰难梭菌感染（CDI）呈上升趋势，且艰难梭菌定植率很高，尤其是在年幼儿童中，但婴儿对该疾病仍具有相当的抵抗力。本研究的目的是区分腹泻儿童与未腹泻儿童的CDI是否存在差异，确定CDI的患病率，并评估本机构中3岁以下腹泻儿童的CDI严重程度。
于2015年5月至2016年6月进行了一项前瞻性研究。将3岁及以下儿童纳入两组。每个粪便样本都使用包括免疫层析试验和聚合酶链反应的诊断性两步筛查算法进行检测。
该研究纳入了147名腹泻儿童和75名对照患者。腹泻儿童中CDI的患病率为2%（3/147），腹泻组中产毒艰难梭菌的患病率与对照组相比为11.6%（17/147）对10.6%（8/75）（p.
