Cognitive and Systems Neuroscience Group, Center for Neuroscience, Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Amsterdam, The Netherlands; Research Priority Program Brain and Cognition, University of Amsterdam, Amsterdam, The Netherlands.
Cognitive and Systems Neuroscience Group, Center for Neuroscience, Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Amsterdam, The Netherlands; Research Priority Program Brain and Cognition, University of Amsterdam, Amsterdam, The Netherlands.
Trends Neurosci. 2019 Sep;42(9):589-603. doi: 10.1016/j.tins.2019.07.005. Epub 2019 Aug 6.
There are three neural feedback pathways to the primary visual cortex (V1): corticocortical, pulvinocortical, and cholinergic. What are the respective functions of these three projections? Possible functions range from contextual modulation of stimulus processing and feedback of high-level information to predictive processing (PP). How are these functions subserved by different pathways and can they be integrated into an overarching theoretical framework? We propose that corticocortical and pulvinocortical connections are involved in all three functions, whereas the role of cholinergic projections is limited by their slow response to stimuli. PP provides a broad explanatory framework under which stimulus-context modulation and high-level processing are subsumed, involving multiple feedback pathways that provide mechanisms for inferring and interpreting what sensory inputs are about.
有三条神经反馈通路到达初级视觉皮层 (V1)：皮质皮质、丘脑皮质和胆碱能。这三种投射的各自功能是什么？可能的功能从刺激处理的上下文调制和高级信息的反馈到预测处理 (PP) 不等。这些功能是由不同的通路来实现的，它们可以整合到一个总体的理论框架中吗？我们提出，皮质皮质和丘脑皮质连接参与了所有这三种功能，而胆碱能投射的作用受到其对刺激反应缓慢的限制。PP 提供了一个广泛的解释框架，其中包括刺激-上下文调制和高级处理，涉及多个反馈通路，为推断和解释感觉输入的内容提供了机制。
