Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA.
Department of Statistics and Biostatistics, University of Michigan, Ann Arbor, MI, USA.
J Cyst Fibros. 2020 Mar;19(2):232-235. doi: 10.1016/j.jcf.2019.07.007. Epub 2019 Aug 6.
The majority of nontuberculous mycobacterial (NTM) pulmonary infections in people with cystic fibrosis (CF) are caused by Mycobacterium avium complex (MAC) species. Data on MAC species distribution and outcomes of infection in CF are lacking.
This was a single center, retrospective study. MAC isolates had species identification with MLSA of rpoB and the 16S23S ITS region. Clinical data were compared between species.
Twenty-three people with CF and 57 MAC isolates were included. Infection with M. avium was the most common (65.2%). M. intracellulare was associated with higher rates of NTM disease, younger age, and steeper decline in lung function prior to infection.
We observed worse clinical outcomes in people with M. intracellulare infection relative to other MAC species. Further investigation of clinical outcomes of MAC infection among CF patients is warranted to better define the utility of species-level identification of MAC isolates in CF.
囊性纤维化（CF）患者中大多数非结核分枝杆菌（NTM）肺部感染是由鸟分枝杆菌复合群（MAC）物种引起的。关于 CF 中 MAC 物种分布和感染结局的数据尚缺乏。
这是一项单中心回顾性研究。MAC 分离株采用 rpoB 和 16S23S ITS 区的 MLSA 进行种属鉴定。比较了不同种属之间的临床数据。
共纳入 23 名 CF 患者和 57 株 MAC 分离株。最常见的感染是鸟分枝杆菌（65.2%）。细胞内分枝杆菌与更高的 NTM 疾病发生率、更年轻的年龄以及感染前肺功能下降更陡峭相关。
与其他 MAC 物种相比，我们观察到细胞内分枝杆菌感染者的临床结局更差。进一步研究 CF 患者 MAC 感染的临床结局，以更好地确定 CF 中 MAC 分离株的种属鉴定的实用性是有必要的。
