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Deletion of miR-451 curbs JAK2(V617F)-induced erythrocytosis in polycythemia vera by oxidative stress-mediated erythroblast apoptosis and hemolysis.

作者信息

Yao Huiyu, Ma Yue, Huang Lily Jun-Shen

机构信息

Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA

出版信息

Haematologica. 2020 Apr;105(4):e153-e156. doi: 10.3324/haematol.2018.210799. Epub 2019 Aug 8.

DOI:10.3324/haematol.2018.210799
PMID:31399524
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7109725/
Abstract
摘要

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Deletion of miR-451 curbs JAK2(V617F)-induced erythrocytosis in polycythemia vera by oxidative stress-mediated erythroblast apoptosis and hemolysis.miR-451的缺失通过氧化应激介导的成红细胞凋亡和溶血抑制真性红细胞增多症中JAK2（V617F）诱导的红细胞增多。
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本文引用的文献

1
Myeloproliferative Neoplasms.骨髓增殖性肿瘤
N Engl J Med. 2017 Jun 1;376(22):2168-2181. doi: 10.1056/NEJMra1406186.
2
Activating JAK2 mutants reveal cytokine receptor coupling differences that impact outcomes in myeloproliferative neoplasm.激活型JAK2突变体揭示了细胞因子受体偶联差异，这些差异影响骨髓增殖性肿瘤的预后。
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Emerging treatments for classical myeloproliferative neoplasms.新兴的经典骨髓增殖性肿瘤治疗方法。
Blood. 2017 Feb 9;129(6):693-703. doi: 10.1182/blood-2016-10-695965. Epub 2016 Dec 27.
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JAK2V617F mediates resistance to DNA damage-induced apoptosis by modulating FOXO3A localization and Bcl-xL deamidation.JAK2V617F通过调节FOXO3A的定位和Bcl-xL的脱酰胺作用介导对DNA损伤诱导的细胞凋亡的抗性。
Oncogene. 2016 Apr 28;35(17):2235-46. doi: 10.1038/onc.2015.285. Epub 2015 Aug 3.
5
Survival and prognosis among 1545 patients with contemporary polycythemia vera: an international study.1545 例当代真性红细胞增多症患者的生存和预后：一项国际研究。
Leukemia. 2013 Sep;27(9):1874-81. doi: 10.1038/leu.2013.163. Epub 2013 Jun 6.
6
Generation of transgenic mouse line expressing Kusabira Orange throughout body, including erythrocytes, by random segregation of provirus method.利用随机整合方法，生成全身（包括红细胞）表达 Kusabira Orange 的转基因鼠系。
Biochem Biophys Res Commun. 2013 Jun 14;435(4):586-91. doi: 10.1016/j.bbrc.2013.05.017. Epub 2013 May 17.
7
A role for reactive oxygen species in JAK2 V617F myeloproliferative neoplasm progression.活性氧在 JAK2 V617F 骨髓增殖性肿瘤进展中的作用。
Leukemia. 2013 Nov;27(11):2187-95. doi: 10.1038/leu.2013.102. Epub 2013 Apr 5.
8
MicroRNA deregulation in polycythemia vera and essential thrombocythemia patients.真性红细胞增多症和原发性血小板增多症患者中 microRNA 的失调。
Blood Cells Mol Dis. 2013 Mar;50(3):190-5. doi: 10.1016/j.bcmd.2012.11.009. Epub 2012 Dec 21.
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MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles.用于心血管疾病的 microRNA 治疗学：机遇与障碍。
Nat Rev Drug Discov. 2012 Nov;11(11):860-72. doi: 10.1038/nrd3864. Epub 2012 Oct 19.
10
Characterization and discovery of novel miRNAs and moRNAs in JAK2V617F-mutated SET2 cells.JAK2V617F 突变 SET2 细胞中新型 miRNA 和 moRNA 的鉴定与发现。
Blood. 2012 Mar 29;119(13):e120-30. doi: 10.1182/blood-2011-07-368001. Epub 2012 Jan 5.