Deletion of miR-451 curbs JAK2(V617F)-induced erythrocytosis in polycythemia vera by oxidative stress-mediated erythroblast apoptosis and hemolysis.
作者信息
Yao Huiyu, Ma Yue, Huang Lily Jun-Shen
机构信息
Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA
出版信息
Haematologica. 2020 Apr;105(4):e153-e156. doi: 10.3324/haematol.2018.210799. Epub 2019 Aug 8.
Abstract
摘要
相似文献
1
Deletion of miR-451 curbs JAK2(V617F)-induced erythrocytosis in polycythemia vera by oxidative stress-mediated erythroblast apoptosis and hemolysis.miR-451的缺失通过氧化应激介导的成红细胞凋亡和溶血抑制真性红细胞增多症中JAK2（V617F）诱导的红细胞增多。
Haematologica. 2020 Apr;105(4):e153-e156. doi: 10.3324/haematol.2018.210799. Epub 2019 Aug 8.
2
JAK2 exon 12 mutations in polycythemia vera or idiopathic erythrocytosis.真性红细胞增多症或特发性红细胞增多症中的JAK2外显子12突变。
Haematologica. 2007 Dec;92(12):1717-8. doi: 10.3324/haematol.12011.
3
JAK2 V617F mutation is rare in idiopathic erythrocytosis: a difference from polycythemia vera.JAK2 V617F突变在特发性红细胞增多症中罕见：与真性红细胞增多症的差异。
Int J Hematol. 2008 Jul;88(1):82-87. doi: 10.1007/s12185-008-0103-6. Epub 2008 Jun 6.
4
Phenotypic variations and new mutations in JAK2 V617F-negative polycythemia vera, erythrocytosis, and idiopathic myelofibrosis.JAK2 V617F阴性真性红细胞增多症、红细胞增多症和原发性骨髓纤维化中的表型变异与新突变。
Exp Hematol. 2007 Nov;35(11):1641-6. doi: 10.1016/j.exphem.2007.08.010. Epub 2007 Oct 17.
5
Characteristics of JAK2 unmutated erythrocytosis: Distinctive traits between polycythemia vera and non-polycythemia vera patients.JAK2未突变的红细胞增多症的特征：真性红细胞增多症与非真性红细胞增多症患者之间的独特性状。
Eur J Intern Med. 2023 Jan;107:113-115. doi: 10.1016/j.ejim.2022.09.004. Epub 2022 Sep 10.
6
Compound in-cis JAK2 mutant polycythemia vera manifesting as first-onset transient ischemic attack with erythrocytosis and an attenuated JAK2 V617F mutant signal on a quantitative DD-PCR assay.复合顺式JAK2突变型真性红细胞增多症表现为首发短暂性脑缺血发作伴红细胞增多症，且在定量DD-PCR检测中JAK2 V617F突变信号减弱。
Int J Lab Hematol. 2023 Apr;45(2):e28-e31. doi: 10.1111/ijlh.13979. Epub 2022 Oct 7.
7
Somatic JAK-2 V617F Mutational Analysis in Polycythemia Rubra Vera: a Tertiary Care Center Experience.真性红细胞增多症的体细胞JAK-2 V617F突变分析：一家三级医疗中心的经验
Asian Pac J Cancer Prev. 2016;17(3):1053-5. doi: 10.7314/apjcp.2016.17.3.1053.
8
The polycythemia vera-associated Jak2 V617F mutant induces tumorigenesis in nude mice.真性红细胞增多症相关的Jak2 V617F突变体在裸鼠中诱导肿瘤发生。
Int Immunopharmacol. 2009 Jul;9(7-8):870-7. doi: 10.1016/j.intimp.2009.03.011. Epub 2009 Mar 25.
9
Diagnostic Performance of Erythropoietin Levels in Polycythemia Vera: Experience at a Comprehensive Cancer Center.真性红细胞增多症中红细胞生成素水平的诊断性能：综合癌症中心的经验。
Clin Lymphoma Myeloma Leuk. 2021 Apr;21(4):224-229. doi: 10.1016/j.clml.2020.11.002. Epub 2020 Nov 5.
10
Detection of JAK2 exon 12 mutations in 15 patients with JAK2V617F negative polycythemia vera.15例JAK2V617F阴性真性红细胞增多症患者中JAK2外显子12突变的检测
Haematologica. 2009 Mar;94(3):414-8. doi: 10.3324/haematol.13223.
引用本文的文献
1
Differences in Pathogenetic Mechanism Between Tibetan and Han High-Altitude Polycythemia Based on a Whole Genome-Wide Association Study.基于全基因组关联研究的藏族与汉族高原红细胞增多症发病机制差异
Phenomics. 2025 Feb 15;5(2):169-182. doi: 10.1007/s43657-024-00180-y. eCollection 2025 Apr.
2
Determination of the role of miR-451a on Plasmodium falciparum red blood cell stages, oxidative stress, and proteomic profiling.确定 miR-451a 在恶性疟原虫红内期、氧化应激和蛋白质组学特征中的作用。
Mol Biol Rep. 2024 Oct 7;51(1):1041. doi: 10.1007/s11033-024-09938-z.
3
To Assess the Role of microRNA-451 in the Progression and Metastasis of Colorectal Cancer.评估微小RNA-451在结直肠癌进展和转移中的作用。
Appl Biochem Biotechnol. 2024 Feb;196(2):1044-1057. doi: 10.1007/s12010-023-04538-2. Epub 2023 Jun 15.
4
MTAP-related increased erythroblast proliferation as a mechanism of polycythaemia vera.MTAP 相关的红细胞增生增多作为真性红细胞增多症的一种机制。
Sci Rep. 2021 Nov 18;11(1):22483. doi: 10.1038/s41598-021-01877-0.
5
miR‑451 suppresses the malignant characteristics of colorectal cancer via targeting SAMD4B.miR-451 通过靶向 SAMD4B 抑制结直肠癌的恶性特征。
Mol Med Rep. 2021 Aug;24(2). doi: 10.3892/mmr.2021.12196. Epub 2021 Jun 10.
本文引用的文献
1
Myeloproliferative Neoplasms.骨髓增殖性肿瘤
N Engl J Med. 2017 Jun 1;376(22):2168-2181. doi: 10.1056/NEJMra1406186.
2
Activating JAK2 mutants reveal cytokine receptor coupling differences that impact outcomes in myeloproliferative neoplasm.激活型JAK2突变体揭示了细胞因子受体偶联差异，这些差异影响骨髓增殖性肿瘤的预后。
Leukemia. 2017 Oct;31(10):2122-2131. doi: 10.1038/leu.2017.1. Epub 2017 Jan 6.
3
Emerging treatments for classical myeloproliferative neoplasms.新兴的经典骨髓增殖性肿瘤治疗方法。
Blood. 2017 Feb 9;129(6):693-703. doi: 10.1182/blood-2016-10-695965. Epub 2016 Dec 27.
4
JAK2V617F mediates resistance to DNA damage-induced apoptosis by modulating FOXO3A localization and Bcl-xL deamidation.JAK2V617F通过调节FOXO3A的定位和Bcl-xL的脱酰胺作用介导对DNA损伤诱导的细胞凋亡的抗性。
Oncogene. 2016 Apr 28;35(17):2235-46. doi: 10.1038/onc.2015.285. Epub 2015 Aug 3.
5
Survival and prognosis among 1545 patients with contemporary polycythemia vera: an international study.1545 例当代真性红细胞增多症患者的生存和预后：一项国际研究。
Leukemia. 2013 Sep;27(9):1874-81. doi: 10.1038/leu.2013.163. Epub 2013 Jun 6.
6
Generation of transgenic mouse line expressing Kusabira Orange throughout body, including erythrocytes, by random segregation of provirus method.利用随机整合方法，生成全身（包括红细胞）表达 Kusabira Orange 的转基因鼠系。
Biochem Biophys Res Commun. 2013 Jun 14;435(4):586-91. doi: 10.1016/j.bbrc.2013.05.017. Epub 2013 May 17.
7
A role for reactive oxygen species in JAK2 V617F myeloproliferative neoplasm progression.活性氧在 JAK2 V617F 骨髓增殖性肿瘤进展中的作用。
Leukemia. 2013 Nov;27(11):2187-95. doi: 10.1038/leu.2013.102. Epub 2013 Apr 5.
8
MicroRNA deregulation in polycythemia vera and essential thrombocythemia patients.真性红细胞增多症和原发性血小板增多症患者中 microRNA 的失调。
Blood Cells Mol Dis. 2013 Mar;50(3):190-5. doi: 10.1016/j.bcmd.2012.11.009. Epub 2012 Dec 21.
9
MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles.用于心血管疾病的 microRNA 治疗学：机遇与障碍。
Nat Rev Drug Discov. 2012 Nov;11(11):860-72. doi: 10.1038/nrd3864. Epub 2012 Oct 19.
10
Characterization and discovery of novel miRNAs and moRNAs in JAK2V617F-mutated SET2 cells.JAK2V617F 突变 SET2 细胞中新型 miRNA 和 moRNA 的鉴定与发现。
Blood. 2012 Mar 29;119(13):e120-30. doi: 10.1182/blood-2011-07-368001. Epub 2012 Jan 5.
Zotero 插件