Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University General Hospital of Larissa, University of Thessaly, Biopolis, 40500, Larissa, Greece.
Department of Neurology and Laboratory of Neurogenetics, Faculty of Medicine, School of Health Sciences, University General Hospital of Larissa, University of Thessaly, Viopolis, 40500, Larissa, Greece.
Immunol Res. 2019 Oct;67(4-5):310-324. doi: 10.1007/s12026-019-09089-5.
Statins, the cholesterol-lowering drugs, also possess immunomodulatory properties, affecting among others T cell activation and differentiation, antigen presentation, and regulatory T cell (Tregs) maintenance and differentiation. Their effects on autoagression have led investigators to assess their clinical significance in autoimmune disease, such as multiple sclerosis (MS), a chronic progressive demyelinating disease of autoimmune nature. The dysregulated immunity noted in MS features a profound shift from Tregs dominance to Th17 cell superiority. In this review, we discuss the immunobiological basis of statins, their role in autoimmunity related to MS, and the data from experimental models and human studies on their effect on Th17 cells.
他汀类药物，即降胆固醇药物，也具有免疫调节特性，影响 T 细胞激活和分化、抗原呈递以及调节性 T 细胞（Tregs）的维持和分化等。它们对自身免疫的影响促使研究人员评估它们在多发性硬化症（MS）等自身免疫性疾病中的临床意义，MS 是一种慢性进行性脱髓鞘疾病。MS 中失调的免疫表现为从 Tregs 优势到 Th17 细胞优势的深刻转变。在这篇综述中，我们讨论了他汀类药物的免疫生物学基础、它们在与 MS 相关的自身免疫中的作用，以及实验模型和人类研究中关于它们对 Th17 细胞影响的数据。
