Zhang Xin, Markovic-Plese Silva
Department of Neurology, University of North Carolina at Chapel Hill, 6109 Neuroscience Research Building, 103 Mason Farm Road, Chapel Hill, NC 27599, USA.
Immunol Res. 2008;41(3):165-74. doi: 10.1007/s12026-008-8019-z.
Statins' recently discovered anti-inflammatory effects place them at the forefront of the new therapies for chronic inflammatory and autoimmune diseases. Our recent study demonstrated that simvastatin exerts an independent immunomodulatory effect on the human monocytes and CD4+ cells. In addition to the statin-mediated effect on the monocyte cytokine production, which regulates Th17 cell differentiation, simvastatin directly inhibits IL-17 production in CD4+ cells, which may collectively inhibit the autoimmune response in multiple sclerosis (MS), a central nervous system (CNS) inflammatory demyelinating disease.
他汀类药物最近发现的抗炎作用使其处于慢性炎症和自身免疫性疾病新疗法的前沿。我们最近的研究表明，辛伐他汀对人单核细胞和CD4+细胞具有独立的免疫调节作用。除了他汀类药物介导的对单核细胞细胞因子产生的影响（调节Th17细胞分化）外，辛伐他汀还直接抑制CD4+细胞中IL-17的产生，这可能共同抑制多发性硬化症（MS，一种中枢神经系统（CNS）炎性脱髓鞘疾病）中的自身免疫反应。
