Department of Chemical Engineering, Hanyang University, Haengdang-dong, Seongdong-gu, Seoul, 04763, South Korea.
Department of Chemical Engineering, Hanyang University, Haengdang-dong, Seongdong-gu, Seoul, 04763, South Korea.
J Chromatogr A. 2019 Dec 6;1607:460394. doi: 10.1016/j.chroma.2019.460394. Epub 2019 Jul 23.
For the high-purity production of acetoin or 2,3-butanediol (BD) from related fermentation processes, it is essential to accomplish a detailed separation between acetoin and BD in an economical mode. To address this issue, we aimed to develop a highly-efficient simulated-moving-bed (SMB) process for the continuous-mode separation of acetoin from BD with high purity and small loss. As a first step for this task, the adsorption and mass-transfer parameters of acetoin and BD on a proven adsorbent were estimated while assuming that BD isomers (meso-BD and DL-BD) would be identical in adsorption and mass-transfer behaviors. The resultant parameters from such estimation were applied to the optimal design of the acetoin-BD separation SMB. The designed SMB was then experimentally investigated, which revealed that some sign of BD isomerism occurred in the SMB column-profile data and thus had an adverse effect on the SMB separation performance. To resolve this problem, the individual parameters of BD isomers were determined on the basis of the SMB column-profile data and an inverse-method principle. The resulting parameters of BD isomers were used in the re-design of the target SMB, which was then experimentally checked for its separation performance. It was confirmed that such SMB re-designed in consideration of BD isomerism was quite effective in the continuous-mode separation of acetoin from BD with high purity (> 99.2%) and small loss (< 1.52%).
为了从相关发酵过程中高纯度生产乙酰丙酮或 2,3-丁二醇（BD），以经济的方式在乙酰丙酮和 BD 之间完成详细的分离至关重要。为了解决这个问题，我们旨在开发一种高效的模拟移动床（SMB）工艺，用于连续模式下以高纯度和小损失从 BD 中分离出乙酰丙酮。作为实现这一目标的第一步，我们假设 BD 异构体（meso-BD 和 DL-BD）在吸附和传质行为上是相同的，对乙酰丙酮和 BD 在经过验证的吸附剂上的吸附和传质参数进行了估计。从这种估计得出的参数被应用于乙酰丙酮-BD 分离 SMB 的最佳设计。然后对设计的 SMB 进行了实验研究，结果表明，SMB 柱形数据中存在一些 BD 异构体的迹象，从而对 SMB 分离性能产生不利影响。为了解决这个问题，根据 SMB 柱形数据和反演方法原理确定了 BD 异构体的各个参数。然后将 BD 异构体的参数用于目标 SMB 的重新设计，并对其分离性能进行了实验验证。结果证实，考虑到 BD 异构体的这种重新设计的 SMB 在连续模式下从 BD 中分离出高纯度（>99.2%）和小损失（<1.52%）的乙酰丙酮非常有效。
