Service de chirurgie viscérale et endocrinienne, CHU Angers, 49933 Angers cedex 9, France.
Unité Inserm 1066 MINT, UFR SPIS, université d'Angers, 49045 Angers, France.
Ann Endocrinol (Paris). 2019 Nov;80(5-6):286-292. doi: 10.1016/j.ando.2019.04.016. Epub 2019 Jul 26.
France is pursuing a policy of cutting healthcare costs, and outpatient surgery is one of the objectives of this policy. Thyroid surgery could be suitable for outpatient management, provided there is an appropriate patient selection process. The aim of this study was to assess the risk factors for postoperative complications in total thyroidectomy (TT).
A single-center observational study was carried out from January 2010 to December 2015.
Correlations between, on the one hand, age, gender, obesity, history of surgery, antiplatelet and/or anticoagulation treatment, the surgeon's experience, surgery time, repeated lymph node dissection, and surgical indication (cancer, lymphocytic thyroiditis, Graves' disease or multinodular goiter) and, on the other hand, onset of postoperative complications (postoperative hypocalcemia, uni- or bi-lateral lesions of the recurrent laryngeal nerves, and premature compressive hematoma) were assessed.
Four hundred and twenty-four consecutive TTs were included. 85 patients showed postoperative hypocalcemia (20.04%), 18 recurrent laryngeal nerve lesion (4.25%), and 4 compressive cervical hematoma (0.94%). Overall morbidity was 24.06%. Risk factors identified for postoperative hypocalcemia comprised: female gender [OR=3.2584; 95%CI (1.5500-7.7515); P=0.0036], surgery time [OR=1.0095; 95%CI (1.0020-1.0172); P=0.0129], and surgical indication for benign adenoma [OR=5.0642; 95%CI (1.7768-14.5904); P=0.0022]. None of the study variables emerged as risk factors for recurrent laryngeal nerve lesion. Repeated dissection increased the risk of re-do surgery for compressive hematoma [OR=25.1373; 95%CI (0.8468-32.2042); P=0.0347].
Surgery time, female gender, repeated dissection and total thyroidectomy for benign adenoma are risk factors that should be considered in decision-making for performing TT on an outpatient basis.
法国正在推行降低医疗成本的政策,门诊手术是该政策的目标之一。甲状腺手术可以适合门诊管理,前提是有适当的患者选择过程。本研究的目的是评估全甲状腺切除术(TT)术后并发症的危险因素。
这是一项单中心观察性研究,于 2010 年 1 月至 2015 年 12 月进行。
一方面,评估年龄、性别、肥胖、手术史、抗血小板和/或抗凝治疗、外科医生经验、手术时间、重复淋巴结清扫术以及手术指征(癌症、淋巴细胞性甲状腺炎、格雷夫斯病或多结节性甲状腺肿)与另一方面,术后并发症(术后低钙血症、单侧或双侧喉返神经损伤和早期压迫性血肿)的发生之间的相关性。
纳入了 424 例连续的 TT。85 例患者出现术后低钙血症(20.04%),18 例出现喉返神经损伤(4.25%),4 例出现颈椎压迫性血肿(0.94%)。总发病率为 24.06%。术后低钙血症的危险因素包括:女性[OR=3.2584;95%CI(1.5500-7.7515);P=0.0036]、手术时间[OR=1.0095;95%CI(1.0020-1.0172);P=0.0129]和良性腺瘤的手术指征[OR=5.0642;95%CI(1.7768-14.5904);P=0.0022]。研究变量均未成为喉返神经损伤的危险因素。重复解剖增加了因压迫性血肿而再次手术的风险[OR=25.1373;95%CI(0.8468-32.2042);P=0.0347]。
手术时间、女性、重复解剖和良性腺瘤的全甲状腺切除术是在门诊进行 TT 决策时应考虑的危险因素。