Shenasa Mohammad
Heart and Rhythm Medical Group, Department of Cardiovascular Services, O'Connor Hospital, San Jose, CA 95030, USA.
Card Electrophysiol Clin. 2019 Sep;11(3):551-562. doi: 10.1016/j.ccep.2019.06.002.
Cardiac fibrosis is a significant increase in collagen volume fraction of myocardial tissue. It plays an important role in the pathophysiology of many cardiovascular abnormalities. Electrophysiologically, myocardial fibrosis produces anisotropic conduction, inhomogeneity, and conduction delay. Several markers are available to detect myocardial fibrosis. CMRI is the most common imaging technique; late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) provides markers for tissue characterization, disease progression and arrhythmic events. LGE-CMR can be used as risk marker of occurrence of pathologic conditions. LGE-CMR demonstrates specific patterns related to different pathologic substrates. We discuss the role of CMRI in ventricular arrhythmogenesis.
心脏纤维化是指心肌组织中胶原容积分数显著增加。它在许多心血管异常的病理生理学中起着重要作用。在电生理方面，心肌纤维化会导致各向异性传导、不均一性和传导延迟。有多种标志物可用于检测心肌纤维化。心脏磁共振成像（CMRI）是最常用的成像技术；钆延迟增强心脏磁共振成像（LGE-CMR）可为组织特征、疾病进展和心律失常事件提供标志物。LGE-CMR可作为病理状况发生的风险标志物。LGE-CMR显示出与不同病理基质相关的特定模式。我们讨论了CMRI在室性心律失常发生中的作用。
