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腹膜细胞学检查在早期结直肠癌患者中的作用。

Role of Peritoneal Cytology in Patients with Early Stage Colorectal Cancer.

机构信息

Department of Surgery, Infanta Cristina Hospital, Carrillo Areanas 20A. Villafranca de los Barros, 06220, Badajoz, Spain.

Department of Surgery, University of Extremadura, Badajoz, Spain.

出版信息

Pathol Oncol Res. 2020 Apr;26(2):1325-1329. doi: 10.1007/s12253-019-00706-0. Epub 2019 Aug 10.

Abstract

The main objective of this study was to investigate the incidence of free tumour cells in peritoneal lavage cytology performed using a standard method before and after the resection of the tumour, and to assess the usefulness of this technique in scheduled interventions on colorectal cancer patients. Peritoneal lavage cytology was performed on a homogeneous sample of 188 patients undergoing colorectal cancer curative resection before and after the resection of the tumour. The procedure was performed systematically in all cases. Malignant cells were detected in the peritoneal lavage cytology performed before the resection of the tumour in three patients. Lymph node affection was the variable most associated with the prognosis of these colorectal cancer patients. Peritoneal lavage cytology can provide additional information for a small group of patients who need to be closely monitored and studied to decide on the most effective type of chemotherapy.

摘要

本研究的主要目的是调查在肿瘤切除前后使用标准方法进行的腹腔灌洗细胞学中游离肿瘤细胞的发生率,并评估该技术在结直肠癌患者计划性干预中的有用性。对 188 例接受结直肠癌根治性切除术的患者在肿瘤切除前后进行了腹腔灌洗细胞学的同质样本检测。所有病例均系统地进行了该操作。在 3 例患者的肿瘤切除前的腹腔灌洗细胞学检查中检测到恶性细胞。淋巴结受累是与这些结直肠癌患者预后最相关的变量。腹腔灌洗细胞学可以为需要密切监测和研究以确定最有效的化疗类型的一小部分患者提供额外的信息。

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