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建立神经源性膀胱患者的预测模型:上尿路损伤预测列线图。

Create a predictive model for neurogenic bladder patients: upper urinary tract damage predictive nomogram.

机构信息

Department of Nursing, Shenzhen Hospital, Southern Medical University , Shenzhen , China.

Department of Nursing, The Third Affiliated Hospital of Sun Yat-Sen University , Guangzhou , China.

出版信息

Int J Neurosci. 2019 Dec;129(12):1240-1246. doi: 10.1080/00207454.2019.1655016. Epub 2019 Sep 2.

Abstract

: To create a nomogram to evaluate the risk of upper urinary tract damage (UUTD) in patients with neurogenic bladder (NGB) : A retrospective analysis was conducted on 301 patients with NGB who were admitted to certain hospitals. Data collected included clinical symptoms, patients' characteristics, laboratory parameters, imaging findings, and urodynamic parameters. The least absolute shrinkage and selection operator(LASSO)regression model was used to optimise the selection of predictors. Multivariate logistic regression analysis was performed to develop a UUTD risk predictive model. Validation was performed by bootstrap. : The predictors included in the nomogram included sex, duration of disease, history of UTI, bladder compliance, and fecal incontinence. The model presented good discrimination with a C-index value of 0.796 (95% confidence interval: 0.74896-0.84304) and good calibration. The C-index value of the interval validation was 0.7872112. The results of decision curve analysis (DCA) demonstrated that the UUTD-risk predictive nomogram was clinically useful. : The nomogram incorporating the sex, duration of disease, history of UTI, bladder compliance, and fecal incontinence could be an important tool of UUTD risk prediction in NGB patients.

摘要

建立一个列线图来评估神经源性膀胱(NGB)患者上尿路损伤(UUTD)的风险:对在特定医院就诊的 301 例 NGB 患者进行了回顾性分析。收集的数据包括临床症状、患者特征、实验室参数、影像学发现和尿动力学参数。最小绝对收缩和选择算子(LASSO)回归模型用于优化预测因子的选择。进行多变量逻辑回归分析以建立 UUTD 风险预测模型。通过自举法进行验证。:列线图中纳入的预测因子包括性别、疾病持续时间、尿路感染史、膀胱顺应性和粪便失禁。该模型具有良好的区分度,C 指数值为 0.796(95%置信区间:0.74896-0.84304),校准度良好。区间验证的 C 指数值为 0.7872112。决策曲线分析(DCA)的结果表明,UUTD 风险预测列线图具有临床实用性。:纳入性别、疾病持续时间、尿路感染史、膀胱顺应性和粪便失禁的列线图可能是 NGB 患者 UUTD 风险预测的重要工具。

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