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体型指数可预测肾移植受者的代谢综合征和胰岛素抵抗。

Body Shape Index Predicts Metabolic Syndrome and Insulin Resistance in Renal Transplant Recipients.

作者信息

Ecder Sabahat Alisir, Sasak Gulsah

机构信息

Department of Nephrology, S.B Medeniyet University Faculty of Medicine, Istanbul, Turkey.

Department of Nephrology, S.B Medeniyet University Goztepe Educational and Research Hospital, Istanbul, Turkey.

出版信息

Transplant Proc. 2019 Sep;51(7):2334-2338. doi: 10.1016/j.transproceed.2019.01.172. Epub 2019 Aug 8.

Abstract

Obesity is one of the most important metabolic diseases around the world. There are no reliable and inexpensive methods to evaluate obesity. All of the anthropometric measurements used have some limitations. In 2012, Krakauer et al developed a new method, called A Body Shape Index (ABSI), to identify abdominal obesity that is derived from weight, height, and waist circumference. In this study, we aimed to investigate the clinical usefulness of the ABSI to predict the presence of insulin resistance (IR) and metabolic syndrome (MetS) in renal transplant recipients. A total of 155 patients were included in the study. Prevalence of IR was 17.4%, and MetS was 62.6%. ROC results demonstrated the power of all anthropometric indices to discriminate patients with and without MetS and IR in the renal transplant populations. ROC curves showed that waist-to-height ratio (WHtR) had the optimal power to discriminate MetS and IR in women. WC had higher area under curve than all other anthropometric indices to predict MetS and IR in men. WC in men and WHtR in women has higher discriminatory capacity to predict MetS and IR in renal transplant recipients. An obvious difference was observed in the optimal anthropometric measures between the 2 sexes, suggesting that sex-specific measures should be used in practice. In order to evaluate the value of ABSI in determining metabolic risk factors, studies with larger, randomized, controlled body fat ratios are needed.

摘要

肥胖是全球最重要的代谢性疾病之一。目前尚无可靠且廉价的肥胖评估方法。所有使用的人体测量方法都存在一定局限性。2012年,克拉考尔等人开发了一种名为身体形状指数(ABSI)的新方法,用于识别由体重、身高和腰围得出的腹部肥胖。在本研究中,我们旨在探讨ABSI预测肾移植受者胰岛素抵抗(IR)和代谢综合征(MetS)的临床实用性。共有155名患者纳入本研究。IR的患病率为17.4%,MetS的患病率为62.6%。ROC结果显示了所有人体测量指标在区分肾移植人群中有无MetS和IR患者方面的能力。ROC曲线表明,腰高比(WHtR)在区分女性MetS和IR方面具有最佳能力。在预测男性MetS和IR方面,腰围(WC)的曲线下面积高于所有其他人体测量指标。男性的WC和女性的WHtR在预测肾移植受者的MetS和IR方面具有更高的鉴别能力。在两种性别之间观察到最佳人体测量指标存在明显差异,这表明在实际应用中应采用针对性别的测量方法。为了评估ABSI在确定代谢危险因素方面的价值,需要开展更大规模、随机对照的体脂率研究。

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