Li Juan, Wang Qian, Wang Liangliang, Wang Jing, Wang Dongxiao, Xin Zhaoqin, Liu Yilin, Zhao Qinghua
Department of Special Inspection, Liaocheng People's Hospital, Liaocheng, Shandong 252000, P.R. China.
Department of Ultrasound, Liaocheng People's Hospital, Liaocheng, Shandong 252000, P.R. China.
Oncol Lett. 2019 Sep;18(3):2316-2321. doi: 10.3892/ol.2019.10584. Epub 2019 Jul 5.
Diagnostic value of fine-needle aspiration (FNA) combined with ultrasound for thyroid cancer was evaluated. A retrospective analysis was performed on the preoperative FNA and ultrasound data of 165 thyroid nodule patients, were divided into group A (≤1 cm group) and group B (>1 cm group) based on the maximum diameter line of the thyroid nodule. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of FNA, ultrasound and FNA combined with ultrasound in the diagnosis of thyroid cancer were analyzed and compared. In group A (≤1 cm group), the sensitivity, specificity, accuracy, positive predictive value and negative predictive value of FNA in the diagnosis of thyroid cancer were 93.33, 71.43, 91.04, 96.55 and 55.56%, respectively, those of ultrasound were 86.67, 28.57, 80.60, 91.23 and 20%, respectively, and those of FNA combined with ultrasound were 100, 28.57, 92.54, 92.6 and 100%, respectively, with statistically significant differences in the sensitivity, specificity, accuracy, positive predictive value and negative predictive value between FNA, ultrasound and FNA combined with ultrasound (P<0.05). In group B, the sensitivity, specificity, accuracy, positive predictive value and negative predictive value of FNA in the diagnosis of thyroid cancer were 100, 54.55, 94.90, 94.57 and 100%, respectively, those of ultrasound were 96.55, 72.73, 93.88, 96.55 and 72.73%, respectively, and those of FNA combined with ultrasound were 100, 63.64, 97.96, 95.92 and 100%, respectively, without statistically significant differences in the sensitivity, specificity, accuracy, positive predictive value and negative predictive value between FNA, ultrasound and FNA combined with ultrasound (P>0.05). FNA combined with ultrasound significantly improved the sensitivity and accuracy in the diagnosis of the thyroid nodule in group A, but it did not significantly improve the accuracy, sensitivity and specificity in the diagnosis of the thyroid nodule in group B.
评估细针穿刺抽吸活检（FNA）联合超声检查对甲状腺癌的诊断价值。对165例甲状腺结节患者的术前FNA和超声检查数据进行回顾性分析，根据甲状腺结节的最大直径线将患者分为A组（≤1 cm组）和B组（>1 cm组）。分析并比较FNA、超声及FNA联合超声在诊断甲状腺癌中的敏感性、特异性、准确性、阳性预测值和阴性预测值。在A组（≤1 cm组）中，FNA诊断甲状腺癌的敏感性、特异性、准确性、阳性预测值和阴性预测值分别为93.33%、71.43%、91.04%、96.55%和55.56%，超声分别为86.67%、28.57%、80.60%、91.23%和20%，FNA联合超声分别为100%、28.57%、92.54%、92.6%和100%，FNA、超声及FNA联合超声在敏感性、特异性、准确性、阳性预测值和阴性预测值方面差异有统计学意义（P<0.05）。在B组中，FNA诊断甲状腺癌的敏感性、特异性、准确性、阳性预测值和阴性预测值分别为100%、54.55%、94.90%、94.57%和100%，超声分别为96.55%、72.73%、93.88%、96.55%和72.73%，FNA联合超声分别为100%、63.64%、97.96%、95.92%和100%，FNA、超声及FNA联合超声在敏感性、特异性、准确性、阳性预测值和阴性预测值方面差异无统计学意义（P>0.05）。FNA联合超声显著提高了A组甲状腺结节诊断的敏感性和准确性，但对B组甲状腺结节诊断的准确性、敏感性和特异性未显著提高。
