Xu Feixue, Si Xiaoqiang, Du Jingran, Xu Feihua, Yang Aihong, Zhang Caixia, Zhang Xiucai, Yang Yongxiu
Department of Gynecology, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China.
Department of Plastic Surgery, The Gansu Provincial Hospital, Lanzhou, Gansu 730000, P.R. China.
Oncol Lett. 2019 Sep;18(3):2477-2483. doi: 10.3892/ol.2019.10542. Epub 2019 Jun 28.
Synaptic cell adhesion molecules (SynCAMs) are single transmembrane proteins that belong to the immunoglobulin superfamily of cell adhesion molecules. In the present study, a decrease in SynCAM levels in ovarian tumor tissues compared with normal tissues is reported; the downregulation was accompanied by the grade malignancy. The observations suggested that SynCAM may be essential for important novel functions in ovarian cancer. Further experiments showed that low SynCAM expression inhibited membrane palmitoylated protein 6 (MPP6) expression, a member of the palmitoylated membrane protein subfamily of peripheral membrane-associated guanylate kinases. In addition, low levels of MPP6 in ovarian tumor tissues correlated with shorter patient survival. A SynCAM-regulated pathway may provide molecular targets for the treatment of ovarian cancer and novel biomarkers to be used in clinical diagnosis.
突触细胞粘附分子（SynCAMs）是属于细胞粘附分子免疫球蛋白超家族的单跨膜蛋白。在本研究中，据报道与正常组织相比，卵巢肿瘤组织中SynCAM水平降低；这种下调与恶性程度相关。这些观察结果表明，SynCAM可能对卵巢癌的重要新功能至关重要。进一步的实验表明，低SynCAM表达抑制了膜棕榈酰化蛋白6（MPP6）的表达，MPP6是外周膜相关鸟苷酸激酶棕榈酰化膜蛋白亚家族的成员。此外，卵巢肿瘤组织中MPP6水平低与患者生存期较短相关。一条由SynCAM调节的途径可能为卵巢癌的治疗提供分子靶点，并为临床诊断提供新的生物标志物。
