Department of Cytobiochemistry, Faculty of Biotechnology, University of Wroclaw, 50-383 Wroclaw Poland.
Research and Development Center, Regional Specialist Hospital, Kamieńskiego 73a, 51-154 Wroclaw, Poland.
Molecules. 2020 Oct 26;25(21):4954. doi: 10.3390/molecules25214954.
Membrane palmitoylated proteins (MPPs) are a subfamily of a larger group of multidomain proteins, namely, membrane-associated guanylate kinases (MAGUKs). The ubiquitous expression and multidomain structure of MPPs provide the ability to form diverse protein complexes at the cell membranes, which are involved in a wide range of cellular processes, including establishing the proper cell structure, polarity and cell adhesion. The formation of MPP-dependent complexes in various cell types seems to be based on similar principles, but involves members of different protein groups, such as 4.1-ezrin-radixin-moesin (FERM) domain-containing proteins, polarity proteins or other MAGUKs, showing their multifaceted nature. In this review, we discuss the function of the MPP family in the formation of multiple protein complexes. Notably, we depict their significant role for cell physiology, as the loss of interactions between proteins involved in the complex has a variety of negative consequences. Moreover, based on recent studies concerning the mechanism of membrane raft formation, we shed new light on a possible role played by MPPs in lateral membrane organization.
膜棕榈酰化蛋白 (MPPs) 是一个更大的多域蛋白家族的一个亚家族，即膜相关鸟苷酸激酶 (MAGUKs)。MPPs 的广泛表达和多域结构提供了在细胞膜上形成多种蛋白质复合物的能力，这些复合物参与了广泛的细胞过程，包括建立适当的细胞结构、极性和细胞黏附。在各种细胞类型中，基于类似原理形成的 MPP 依赖性复合物，但涉及不同蛋白质组的成员，如 4.1-埃兹蛋白- radixin-moesin (FERM) 结构域包含蛋白、极性蛋白或其他 MAGUKs，显示其多面性。在这篇综述中，我们讨论了 MPP 家族在多种蛋白质复合物形成中的功能。值得注意的是，我们描述了它们对细胞生理学的重要作用，因为参与复合物的蛋白质之间相互作用的丧失会产生多种负面影响。此外，基于最近关于膜筏形成机制的研究，我们为 MPPs 在侧向膜组织中的可能作用提供了新的认识。
