Department of Natural Products Chemistry, School of Pharmacy , Fudan University , 826 Zhangheng Road , Shanghai 201203 , China.
J Org Chem. 2019 Sep 6;84(17):11261-11267. doi: 10.1021/acs.joc.9b01545. Epub 2019 Aug 22.
An efficient approach to access functionalized 1,4- and 1,5-amino alcohols has been developed through the nucleophilic addition of semicyclic ,-acetal with organozinc reagents. A number of substituted benzyl zinc reagents (including nitrile and ester substituted) could react with semicyclic ,-acetals and , affording the desired products - and - in good to excellent yields.
一种通过半环缩醛与有机锌试剂的亲核加成来获得功能化的 1,4-和 1,5-氨基醇的有效方法已经被开发出来。许多取代的苄基锌试剂（包括腈和酯取代的）可以与半环缩醛和反应，得到所需的产物和，产率良好至优秀。
