From the Division of Gastroenterology, Allegheny Health Network, Pittsburgh, PA.
Department of Internal Medicine, MetroHealth Medical Center, Case Western University, Cleveland, OH.
Pancreas. 2019 Sep;48(8):1098-1101. doi: 10.1097/MPA.0000000000001367.
Acute and/or chronic pancreatitis has been implicated as an important risk factor for pancreatic cancer; however, the incidence and temporal relationship of pancreatitis before pancreatic cancer diagnosis are unclear. We aim to understand the role and incidence of pancreatitis temporally with the development of pancreatic cancer.
A population-based study was used to investigate a temporal relationship between pancreatitis and pancreatic cancer diagnoses. Intervals of 3, 6, 12, 24, and 36 months were developed. Demographical data including age, sex, and race were also recorded and analyzed.
A total of 50,080 patients were found to have a diagnosis of pancreatic cancer, of which 7420 (14.8%) had prior diagnoses of pancreatitis. Of those, 92% were between the ages of 40 and 89 years. African Americans had a higher rate of pancreatitis before cancer diagnosis when compared with whites (21.2% vs 14.8%, P < 0.0001). Further analysis revealed that pancreatitis occurred in 81.3% of patients 3 months before a diagnosis of pancreas cancer and 98.9% had established diagnoses of pancreatic cancer within 3 years.
Screening of patients older than 40 years who have pancreatitis and unclear etiology of pancreatitis may be warranted, especially in African Americans and male individuals.
急性和/或慢性胰腺炎被认为是胰腺癌的一个重要危险因素；然而，胰腺炎在胰腺癌诊断前的发生率和时间关系尚不清楚。我们旨在了解胰腺炎在胰腺癌发展过程中的作用和时间发生率。
本研究采用基于人群的研究方法来调查胰腺炎与胰腺癌诊断之间的时间关系。分别设定了 3、6、12、24 和 36 个月的时间间隔。还记录并分析了人口统计学数据，包括年龄、性别和种族。
共发现 50080 例胰腺癌患者，其中 7420 例（14.8%）有胰腺炎既往诊断。其中，92%的患者年龄在 40 至 89 岁之间。与白人相比，非裔美国人在癌症诊断前患有胰腺炎的比例更高（21.2%比 14.8%，P<0.0001）。进一步分析显示，81.3%的患者在胰腺癌诊断前 3 个月内患有胰腺炎，98.9%的患者在 3 年内确诊为胰腺癌。
对于年龄大于 40 岁且病因不明的胰腺炎患者，特别是非裔美国人和男性患者，可能需要进行筛查。
