Department of Laboratory Medicine, Kyung Hee University Hospital, Kyung Hee University School of Medicine, Seoul, Korea.
Departments of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Korea.
PLoS One. 2022 Oct 27;17(10):e0274195. doi: 10.1371/journal.pone.0274195. eCollection 2022.
The number of patients with diabetes and impaired fasting blood glucose in Korea is rapidly increasing compared to the past, and other metabolic indicators of population are also changed in recent years. To clarify the mechanism more clearly, we investigated the association between fasting blood glucose and incidence of pancreatic cancer in this retrospective cohort study.
In Korea National Health Information Database, 19,050 participants without pancreatic cancer in 2009 were enrolled, and followed up until 2013. We assessed the risk of incident pancreatic cancer according to the quartile groups of fasting blood glucose level (quartile 1: <88 mg/dL, quartile 2: 88-97 mg/dL, quartile 3: 97-109 mg/dL and quartile 4: ≥109 mg/dL). Multivariate Cox-proportional hazard model was used in calculating hazard ratios (HRs) and 95% confidence interval (CI) for incident pancreatic cancer.
Compared with quartile1 (reference), unadjusted HRs and 95% CI for incident pancreatic cancer significantly increased in order of quartile2 (1.39 [1.01-1.92]), quartile3 (1.50 [1.09-2.07]) and quartile4 (2.18 [1.62-2.95]), and fully adjusted HRs and 95% CI significantly increased from quartile2 (1.47 [1.05-2.04]), quartile3 (1.61 [1.05-2.04]) to quartile4 (2.31 [1.68-3.17]).
Fasting blood glucose even with pre-diabetic range was significantly associated with the incident pancreatic cancer in Korean.
与过去相比，韩国的糖尿病和空腹血糖受损患者数量迅速增加，近年来，人群的其他代谢指标也发生了变化。为了更清楚地阐明机制，我们在这项回顾性队列研究中调查了空腹血糖与胰腺癌发病之间的关系。
在韩国国家健康信息数据库中，纳入了 2009 年无胰腺癌的 19050 名参与者，并随访至 2013 年。我们根据空腹血糖水平的四分位组（四分位 1：<88mg/dL；四分位 2：88-97mg/dL；四分位 3：97-109mg/dL；四分位 4：≥109mg/dL）评估了发生胰腺癌的风险。使用多变量 Cox 比例风险模型计算发生胰腺癌的风险比（HRs）和 95%置信区间（CI）。
与四分位 1（参考）相比，未经调整的 HRs 和 95%CI 按四分位 2（1.39[1.01-1.92]）、四分位 3（1.50[1.09-2.07]）和四分位 4（2.18[1.62-2.95]）的顺序显著增加，经完全调整的 HRs 和 95%CI 也从四分位 2（1.47[1.05-2.04]）、四分位 3（1.61[1.05-2.04]）显著增加至四分位 4（2.31[1.68-3.17]）。
即使空腹血糖处于糖尿病前期范围，也与韩国胰腺癌的发病显著相关。
