妊娠对大鼠颞下颌关节伤害感受的影响。
Effect of Pregnancy on TMJ Nociception in Rats.
作者信息
Umorin Mikhail, Bellinger Larry L, Kramer Phillip R
机构信息
Texas A&M University College of Dentistry, 3302 Gaston Avenue, Dallas TX 75246, USA.
出版信息
Kou Qiang Yi Xue Yan Jui. 2018 Mar;34(3):332-338. doi: 10.13701/j.cnki.kqyxyj.2018.03.029.
OBJECTIVE
Does TMJ nociception, as measured by a behavioral assay, differ during pregnancy, potentially due to the effect of sex steroids?
METHODS
Thirty - two Sprague Dawlcy rats were randomly allocated to either mid- (EH 11) or late- (EH 17) pregnancy groups. The animals within each group were further allocated to a saline or CFA treatment. At EH 11 or EH 17, the animals were injected bilaterally into TMJ with either saline (15 L.) or 1 g/L CFA (15 L). Nociception was measured with a feeding assay (pellet recording) and analyzed by comparing in-tra-meal rates using a distance-based permutation method.
RESULTS
CFA injection resulted in the animals eating longer in both the mid - pregnant and late-pregnant groups. Plasma estradiol was higher in the late - pregnant group versus the mid - pregnant group. Importantly, the CFA injected late-pregnant group ate for a shorter amount of time (i. e., shorter meal rate) than the CFA injected rats at mid - pregnancy.
CONCLUSION
The reduced nociceptive response (shorter meal rate) in the CFA injected late - pregnant group may be due to greater estradiol versus the CFA injected mid - pregnancy rats. Thus, one potential reason why women report fewer TMJ symptoms during pregnancy is the higher level of circulating estradiol.
目的
通过行为学检测所测量的颞下颌关节伤害感受在孕期是否存在差异，这可能是由于性类固醇激素的作用？
方法
32只斯普拉格-道利大鼠被随机分配至妊娠中期（妊娠第11天）或晚期（妊娠第17天）组。每组动物再进一步分为生理盐水或弗氏完全佐剂（CFA）处理组。在妊娠第11天或第17天，给动物双侧颞下颌关节注射生理盐水（15微升）或1克/升CFA（15微升）。通过进食检测（颗粒记录）测量伤害感受，并使用基于距离的排列方法比较餐内速率进行分析。
结果
注射CFA导致妊娠中期和晚期组的动物进食时间延长。晚期妊娠组的血浆雌二醇水平高于中期妊娠组。重要的是，与妊娠中期注射CFA的大鼠相比，晚期妊娠注射CFA组的进食时间更短（即进餐速率更低）。
结论
晚期妊娠注射CFA组伤害感受反应降低（进餐速率更低）可能是由于与妊娠中期注射CFA的大鼠相比雌二醇水平更高。因此，女性在孕期报告较少颞下颌关节症状的一个潜在原因是循环雌二醇水平较高。
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