Section of Gastroenterology, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts.
National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts.
Clin Gastroenterol Hepatol. 2020 Jul;18(8):1884-1886. doi: 10.1016/j.cgh.2019.08.003. Epub 2019 Aug 9.
Nonalcoholic fatty liver disease (NAFLD) is associated with increased liver- and cardiovascular disease (CVD)-related morbidity and mortality. In cross-sectional analyses, NAFLD clusters with several cardiometabolic traits including obesity, hypertension, diabetes, and dyslipidemia. However, liver fat is dynamic and changes over time. Aside from limited prior studies evaluating diet or exercise interventions, little is known about the association between changes in liver fat and the incidence of CVD risk factors. Additionally, previous studies often have limited follow-up; evaluate only select populations, such as individuals with obesity or diabetes; and may not account for changes in weight or body mass index (BMI). The aim of the present study was to examine, in a longitudinal cohort, the natural history of liver fat change and the association with the incidence of multiple CVD risk factors.
非酒精性脂肪性肝病（NAFLD）与肝脏和心血管疾病（CVD）相关发病率和死亡率的增加有关。在横断面分析中，NAFLD 与多种心血管代谢特征聚集在一起，包括肥胖、高血压、糖尿病和血脂异常。然而，肝脏脂肪是动态变化的，随时间而变化。除了有限的先前评估饮食或运动干预的研究外，对于肝脏脂肪变化与 CVD 危险因素的发生率之间的关联知之甚少。此外，先前的研究往往随访时间有限；仅评估特定人群，如肥胖或糖尿病患者；并且可能没有考虑体重或体重指数（BMI）的变化。本研究的目的是在纵向队列中检查肝脏脂肪变化的自然史及其与多种 CVD 危险因素发生的关联。
