肝脏脂肪增加与心血管危险因素的进展相关。
Increasing liver fat is associated with progression of cardiovascular risk factors.
作者信息
Brunner Katherine T, Pedley Alison, Massaro Joseph M, Hoffmann Udo, Benjamin Emelia J, Long Michelle T
机构信息
Section of Gastroenterology, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA.
National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.
出版信息
Liver Int. 2020 Jun;40(6):1339-1343. doi: 10.1111/liv.14472. Epub 2020 Apr 24.
Abstract
BACKGROUND
Nonalcoholic fatty liver disease is associated with cardiovascular risk factors in cross-sectional analyses. However, less is known about how changes in liver fat associate with the progression of cardiovascular risk factors.
METHODS
A substudy (n = 808) drawn from the Framingham Heart Study underwent serial computed tomography scans 6 years apart. We performed multivariable-adjusted regression to determine the association between changes in liver fat and progression of cardiovascular risk factors.
RESULTS
Each standard deviation increase in liver fat was associated with adverse progression of systolic blood pressure, diastolic blood pressure, fasting glucose, high-density lipoprotein and log triglycerides. After adjusting for baseline cardiovascular risk, baseline body mass index (BMI), and change in BMI, increasing liver fat was significantly associated with adverse changes in fasting glucose and triglycerides.
CONCLUSIONS
In a longitudinal cohort, increasing liver fat over 6 years was associated with progression of cardiovascular risk factors, even after accounting for BMI changes.
摘要
背景
在横断面分析中，非酒精性脂肪性肝病与心血管危险因素相关。然而，关于肝脏脂肪变化如何与心血管危险因素的进展相关，人们了解较少。
方法
从弗雷明汉心脏研究中抽取的一项子研究（n = 808）每隔6年进行一次系列计算机断层扫描。我们进行多变量调整回归，以确定肝脏脂肪变化与心血管危险因素进展之间的关联。
结果
肝脏脂肪每增加一个标准差，与收缩压、舒张压、空腹血糖、高密度脂蛋白和甘油三酯对数的不良进展相关。在调整了基线心血管风险、基线体重指数（BMI）和BMI变化后，肝脏脂肪增加与空腹血糖和甘油三酯的不良变化显著相关。
结论
在一个纵向队列中，即使考虑了BMI变化，6年内肝脏脂肪增加仍与心血管危险因素的进展相关。
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2
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3
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8
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9
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