Department of Clinical Chemistry, Faculty of Allied Health Science, Chulalongkorn University, Bangkok, Thailand.
Siriraj Research Group in Immunobiology and Therapeutic Sciences, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Biomed Pharmacother. 2019 Oct;118:109319. doi: 10.1016/j.biopha.2019.109319. Epub 2019 Aug 9.
Clerodendrum petasites S. Moore has been prescribed in Thai traditional medicine for over 30 years for the treatment of ailments including asthma, inflammation, fever, cough, vomiting, and skin disorders. The phytochemicals from this plant have been identified as phenolic acids, flavones, flavone glycosides, glycosides, phenylpropanoid, and diterpenoid. The pharmacological activities both in vitro and in vivo have mostly been reported from crude extracts and not from pure compounds. This review, therefore, brings together information on the specific phytochemicals found in C. petasites in order to provide a guide to the natural bioactive compounds that are potentially used in medicines together with mechanisms underlying their pharmacological uses. All relevant information was searched for the terms of plant name, naturally-occurring compounds, and traditional uses from reliable databases, such as PubMed, Science Direct and Google Scholar, along with Thai traditional medicine textbooks. There was no specific timeline set for the search and this review selected to report only mechanisms studied by using standard compounds for their biological activities. Four dominant compounds comprising hispidulin, vanillic acid, verbascoside, and apigenin, have robust evidence to support their medical effects. Hispidulin was discovered to be possibly responsible for the treatment of cancer, osteolytic bone diseases, and neurological diseases. Other compounds were also found to tentatively support the uses in inflammation and neurological diseases. C. petasites extracts may provide an option as complimentary medicine, and or for the pharmacological development of new drugs derived from the phytochemicals found within.
珙桐已在泰国传统医学中使用了 30 多年，用于治疗哮喘、炎症、发热、咳嗽、呕吐和皮肤疾病等疾病。该植物的植物化学物质已被鉴定为酚酸、黄酮、黄酮糖苷、糖苷、苯丙素和二萜。无论是在体外还是体内的药理活性大多都是从粗提取物中报道的，而不是从纯化合物中报道的。因此，本综述汇集了关于珙桐中发现的特定植物化学物质的信息，以便为可能用于药物的天然生物活性化合物提供指南，并为其药理作用的机制提供指南。从可靠的数据库（如 PubMed、Science Direct 和 Google Scholar）以及泰国传统医学教科书，使用植物名称、天然存在的化合物和传统用途等术语搜索了所有相关信息。搜索没有特定的时间表，本综述选择仅报告使用标准化合物研究其生物活性的机制。四种主要化合物，包括木犀草素、香草酸、毛蕊花糖苷和芹菜素，有强有力的证据支持它们的医疗效果。木犀草素被发现可能有助于治疗癌症、溶骨性骨疾病和神经疾病。其他化合物也被发现暂时支持在炎症和神经疾病中的应用。珙桐提取物可能是一种补充药物的选择，也可能是从植物化学物质中开发新药物的药理学发展的选择。
