Department of Gynecology, No.1 Teaching Hospital, China Medical University, Shenyang 110001, China.
Department of Gynecology, No.1 Teaching Hospital, China Medical University, Shenyang 110001, China.
Int Immunopharmacol. 2019 Oct;75:105785. doi: 10.1016/j.intimp.2019.105785. Epub 2019 Aug 9.
Endogenous opioids are neuro-peptides with multifunctional properties. Historically, opioids are used to mediate pain; however, excess opiate consumption can lead to addiction. One endogenous opioid, methionine enkephalin (MENK), was reported to modulate cell growth, MENK was identified as an opioid growth factor (OGF) that interacts with the OGF receptor (OGFr) and regulates cell proliferation. Further, opioid antagonists, including naltrexone and naloxone are widely used to reverse drug and alcohol overdoses. Naltrexone (NTX) acts on all opioid receptors, blocking the interaction between OGF and OGFr, and thus influencing cell growth. During the last decades, insights have been made concerning the interaction between OGF and OGFr, confirming that both opioids and opioid antagonists have an important role in balancing host homeostasis, host immunity and mediating cancer therapy. This review provides insight into the interactions between OGF and OGFr in the treatment of cancers.
内源性阿片肽是具有多功能特性的神经肽。从历史上看，阿片类药物被用于缓解疼痛；然而，过量使用阿片类药物会导致成瘾。一种内源性阿片肽，蛋氨酸脑啡肽（MENK），被报道调节细胞生长，MENK 被鉴定为一种与阿片样生长因子受体（OGFr）相互作用并调节细胞增殖的阿片样生长因子（OGF）。此外，包括纳曲酮和纳洛酮在内的阿片类拮抗剂被广泛用于逆转药物和酒精过量。纳曲酮（NTX）作用于所有阿片受体，阻断 OGF 与 OGFr 之间的相互作用，从而影响细胞生长。在过去的几十年中，人们对 OGF 与 OGFr 之间的相互作用有了深入的了解，证实阿片类药物和阿片类拮抗剂在平衡宿主内稳态、宿主免疫和介导癌症治疗方面都发挥着重要作用。本综述深入探讨了 OGF 与 OGFr 之间在癌症治疗中的相互作用。
