一名因肺炎支原体感染导致多神经根神经病患者体内免疫球蛋白M与唾液酸乳糖胺基副球蛋白的结合情况。

IgM binding to sialosyllactosaminylparagloboside in a patient with polyradiculoneuropathy due to Mycoplasma pneumoniae infection.

作者信息

Inuzuka T, Miyatani N, Baba H, Tanaka M, Tanaka K, Sato S, Nakamura K, Miyatake T

机构信息

Department of Neurology, Niigata University, Japan.

出版信息

Acta Neurol Scand. 1988 Jul;78(1):53-7. doi: 10.1111/j.1600-0404.1988.tb03619.x.

DOI:10.1111/j.1600-0404.1988.tb03619.x

PMID:3140569

Abstract

IgM in serum without paraprotein in a patient with polyradiculoneuropathy due to a Mycoplasma pneumoniae infection reacted specifically with a ganglioside, sialosyllactosaminylparagroboside (SLPG), in a human peripheral nerve on a thin-layer chromatogram plate by an immunostaining technique. This finding suggests the possibility that anti-SLPG antibody in the patient's serum may play a role in the pathogenesis of neuropathy.

摘要

一名因肺炎支原体感染导致多神经根神经病的患者，其血清中无副蛋白的IgM通过免疫染色技术在薄层色谱板上与人周围神经中的一种神经节苷脂——唾液酸乳糖胺基副格罗布苷（SLPG）发生特异性反应。这一发现提示，患者血清中的抗SLPG抗体可能在神经病变的发病机制中起作用。