支原体肺炎感染中枢神经系统表现患儿的抗中心粒自身抗体
Anticentriolar autoantibodies in children with central nervous system manifestations of Mycoplasma pneumoniae infection.
作者信息
Cimolai N, Mah D, Roland E
机构信息
Department of Pathology, University of British Columbia, Vancouver, Canada.
出版信息
J Neurol Neurosurg Psychiatry. 1994 May;57(5):638-9. doi: 10.1136/jnnp.57.5.638.
Abstract
Serum samples from 49 children with acute Mycoplasma pneumoniae infection were screened for the presence of antibodies to mitotic spindle apparatus. None of these serum samples showed such antibodies at a screening dilution of 1:40, though anticentriolar antibodies at titres of 1:320 were observed in two children with acute cerebellar dysfunction. Anticentriolar antibodies may play a part in the pathogenesis of CNS disease associated with M pneumoniae infection.
摘要
对49名急性肺炎支原体感染儿童的血清样本进行检测，以筛查是否存在抗有丝分裂纺锤体装置的抗体。在1:40的筛查稀释度下，这些血清样本均未显示出此类抗体，不过在两名患有急性小脑功能障碍的儿童中观察到了效价为1:320的抗中心粒抗体。抗中心粒抗体可能在与肺炎支原体感染相关的中枢神经系统疾病发病机制中起作用。
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