脂氧合酶代谢产物作为血小板活化因子诱导豚鼠气道对组胺反应性增加的介质。
Lipoxygenase metabolites as mediators of platelet activating factor-induced increased airways responsiveness to histamine in the guinea-pig.
作者信息
Anderson G P, Fennessy M R
机构信息
Department of Pharmacology, University of Melbourne, Parkville, Victoria, Australia.
出版信息
Agents Actions Suppl. 1988;23:195-200. doi: 10.1007/978-3-0348-9156-1_14.
PMID:3140616
Abstract
Inhibitors of platelet activating factor (PAF) and leukotriene synthesis or action are of interest as potential anti-asthmatic drugs. The present study outlines evidence suggesting an interaction between PAF and lipoxygenase products mediating increased airways responsiveness to histamine in vivo.
摘要
血小板活化因子（PAF）抑制剂以及白三烯合成或作用抑制剂作为潜在的抗哮喘药物备受关注。本研究概述了一些证据，这些证据表明PAF与脂氧合酶产物之间存在相互作用，这种相互作用在体内介导了气道对组胺反应性的增强。
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