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The effect of prophylactic anti-asthma drugs on PAF-induced airway hyperreactivity.

作者信息

Sanjar S, Smith D, Schaeublin E, Kristersson A, Chapman I, Mazzoni L, Morley J

机构信息

Preclinical Research, Sandoz AG, Basel, Switzerland.

出版信息

Jpn J Pharmacol. 1989 Oct;51(2):151-60. doi: 10.1254/jjp.51.151.

DOI:10.1254/jjp.51.151
PMID:2574244
Abstract

Intravenous injection of platelet activating factor (PAF) in anesthetized guinea pigs induces non-selective airway hyperreactivity. This response to PAF was reduced in a dose-dependent manner by systemic administration of established prophylactic anti-asthma drugs (ketotifen, cromoglycate, aminophylline and glucocorticosteroids) and by competitive antagonists of PAF. These inhibitory effects could not be accounted for by antagonism of histamine (H1), serotonin or peptidoleukotrienes receptors; parasympatholytic activity; cyclo-oxygenase or lipoxygenase inhibition; mast cell stabilization; or bronchodilatation. Infusion or injection of PAF to induce airway hyperreactivity in the guinea pig may provide a prospective test for prophylactic anti-asthma drugs.

摘要

相似文献

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引用本文的文献

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Effects of a potassium channel opener (SDZ PCO 400) on guinea-pig and human pulmonary airways.
钾通道开放剂（SDZ PCO 400）对豚鼠和人类肺气道的作用。
Br J Pharmacol. 1992 Jun;106(2):423-9. doi: 10.1111/j.1476-5381.1992.tb14350.x.