Lee Shok Yin, Nguyen Phan, Chapman Sally
Department of Thoracic Medicine Royal Adelaide Hospital Adelaide South Australia Australia.
Adelaide Medical School, Faculty of Health and Medical Sciences The University of Adelaide Adelaide South Australia Australia.
Respirol Case Rep. 2019 Aug 7;7(7):e00473. doi: 10.1002/rcr2.473. eCollection 2019 Oct.
Invasive tracheobronchial aspergillosis is a rare disease with most reported cases in the literature occurring in immunocompromised hosts. We report an unusual case of a patient with persistent cough and dyspnoea in the context of prior chemoradiotherapy for primary lung cancer. Chest computed tomography (CT) demonstrated an abnormal soft tissue mass surrounding the trachea and carina, with focal moderate fluorodeoxyglucose (FDG) activity on positron emission tomography (PET) scan. Bronchoscopic biopsy revealed fungal hyphae associated with necrosis and cartilage invasion, subsequently confirmed to be Aspergillus fumigatus complex. The patient was commenced on antifungal therapy promptly and had a good clinical response to treatment.
侵袭性气管支气管曲霉病是一种罕见疾病，文献报道的大多数病例发生在免疫功能低下的宿主中。我们报告了一例不寻常的病例，该患者在接受原发性肺癌的放化疗后持续咳嗽、呼吸困难。胸部计算机断层扫描（CT）显示气管和隆突周围有异常软组织肿块，正电子发射断层扫描（PET）显示局灶性中度氟脱氧葡萄糖（FDG）活性。支气管镜活检显示真菌菌丝伴有坏死和软骨侵犯，随后证实为烟曲霉复合体。患者立即开始抗真菌治疗，对治疗有良好的临床反应。
