Nadeev A P, Orynbasarov S O, Zholmurzaev B T
Novosibirsk State Medical University, Ministry of Health of Russia, Novosibirsk, Russia.
Social Health Insurance Fund, Branch in the Kyzylorda Region, Kyzylorda, Republic of Kazakhstan.
Arkh Patol. 2019;81(4):48-52. doi: 10.17116/patol20198104148.
To study the trend in the incidence and nosological structure of congenital malformations (CMFs) in the fetuses and babies of the Kyzylorda Region (Aral Sea Region) of the Republic of Kazakhstan in the period 2016-2018.
Over 2016-2018, the investigators analyzed 550 childbirth histories, the protocol (records) of autopsy in fetuses and babies who had died at the maternity hospitals and children's hospitals of the Kyzylorda Region (Aral Sea Region, Kazakhstan).
Throughout the follow-up period, the structure of CMFs in the Kyzylorda Region, the Republic of Kazakhstan, was found to have 3 major systemic defects: multiple defects; cardiovascular defects, and central nervous system defects, which can be considered as an indicator for environmental problems in the region. There was a preponderance of hydrocephalus and anencephaly among the CMF of the central nervous system and that of interventricular and interatrial septal defects and combined defects among the cardiovascular CMFs. In the considered period of time, malformations of the urinary system, gastrointestinal tract, and lungs were often observed as part of multiple malformations. In the considered period of time, defects of the urinary system, gastrointestinal tract, and lungs were often observed as part of multiple malformations. The postmortem findings indicated that the conformity of clinical and postmortem CMF diagnoses in the Kyzylorda Region were more than 77%.
研究2016 - 2018年哈萨克斯坦共和国克孜勒奥尔达州（咸海地区）胎儿和婴儿先天性畸形（CMFs）的发病率及疾病分类结构趋势。
在2016 - 2018年期间，研究人员分析了550份分娩记录，以及在哈萨克斯坦克孜勒奥尔达州（咸海地区）妇产医院和儿童医院死亡的胎儿和婴儿的尸检报告（记录）。
在整个随访期间，发现哈萨克斯坦共和国克孜勒奥尔达州先天性畸形的结构有3种主要的系统性缺陷：多发缺陷；心血管缺陷和中枢神经系统缺陷，这可被视为该地区环境问题的一个指标。在中枢神经系统先天性畸形中脑积水和无脑儿占优势，在心血管先天性畸形中室间隔和房间隔缺损及合并缺损占优势。在研究期间，泌尿系统、胃肠道和肺部畸形常作为多发畸形的一部分被观察到。尸检结果表明，克孜勒奥尔达州临床和尸检先天性畸形诊断的符合率超过77%。
