Timakova A A, Saltykov B B
Akad. A.I. Strukov Department of Pathologic Anatomy, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
Arkh Patol. 2019;81(4):78-82. doi: 10.17116/patol20198104178.
The study of the sociomedical problems of diabetes mellitus led to the discovery of latent autoimmune diabetes in adults (LADA), a special form of the disease. The slow onset of the disease, the clinical signs of type 2 diabetes mellitus concurrent with the autoantibody pancreatic β-cell destruction mechanism that is characteristic of type 1 diabetes. Genetic factors play an important role in the genesis of the disease. Insulitis concurrent with intact or hypertrophic islets of the gland originally develops morphologically. Subsequently, the phenomena of islet atrophy and sclerosis are progressive. The disease is typical for young people (generally those aged 25-35 years) with normal body mass index, low blood C-peptide levels, with antibodies against β-cells, primarily to glutamate decarboxylase, being detected. Insulin preparations should be used to treat these patients.
对糖尿病社会医学问题的研究导致了成人隐匿性自身免疫性糖尿病（LADA）这一特殊疾病形式的发现。该疾病起病缓慢，具有2型糖尿病的临床症状，同时伴有1型糖尿病特有的自身抗体介导的胰岛β细胞破坏机制。遗传因素在该疾病的发生中起重要作用。最初在形态学上表现为胰岛完整或肥大的情况下并发胰岛炎。随后，胰岛萎缩和硬化现象逐渐加重。该疾病在体重指数正常、血液C肽水平低、检测到针对β细胞的抗体（主要是谷氨酸脱羧酶抗体）的年轻人（一般为25 - 35岁）中较为典型。应使用胰岛素制剂治疗这些患者。
